Investigating the role of fluctuating events in the cellular environment

研究细胞环境中波动事件的作用

• 批准号: 2606056
• 金额: --
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2606056
• 关键词: Investigating; role; fluctuating; events; cellular

Complex diseases are often caused or affected by multifactorial influences including environment, genetics and a probability element. Extracellular matrix (ECM) remodelling is a poorly explored factor despite its established connection to gene expression via mechanotransduction that is linked to disease and drug resistance. ECM remodelling appears to occur randomly in space and time. In a mechanobiology context, biomaterials providing temporal or spatial variations is in its infancy. This project explores the idea that the degree of randomness of ECM remodelling relates to alterations in biological behaviour, thus contributing to disease development and providing analytic markers and therapeutic targets. In this project, a combined approach of experimental data generation through the development of new biomaterials, paired with computational and mathematical description of the interplay between random stimuli exposure and cell behaviour will provide new insight in the origin, prevention and management of diseases.

复杂的疾病往往是由多因素影响引起或影响的，包括环境、遗传和概率因素。细胞外基质(ECM)重塑是一个研究较少的因素，尽管它通过与疾病和耐药性相关的机械转导与基因表达建立了联系。ECM重塑似乎在空间和时间上随机发生。在机械生物学的背景下，提供时间或空间变化的生物材料还处于初级阶段。该项目探讨了ECM重塑的随机性程度与生物行为的改变有关的想法，从而促进了疾病的发展，并提供了分析标记和治疗目标。在这个项目中，通过开发新的生物材料产生实验数据的综合方法，再加上随机刺激暴露和细胞行为之间相互作用的计算和数学描述，将为疾病的起源、预防和管理提供新的见解。