Investigating the role of fluctuating events in the cellular environment

复杂疾病通常是由多因素影响引起或影响的，包括环境、遗传和概率因素。细胞外基质（ECM）重塑是一个很少被探索的因素，尽管它通过与疾病和耐药性相关的机械转导与基因表达建立了联系。ECM重构在空间和时间上似乎是随机发生的。在机械生物学的背景下，提供时间或空间变化的生物材料还处于起步阶段。该项目探讨了ECM重塑的随机性程度与生物行为的改变有关，从而有助于疾病的发展，并提供分析标记和治疗靶点。在这个项目中，通过开发新的生物材料生成实验数据的结合方法，与随机刺激暴露与细胞行为之间相互作用的计算和数学描述相结合，将为疾病的起源、预防和管理提供新的见解。

Complex diseases are often caused or affected by multifactorial influences including environment, genetics and a probability element. Extracellular matrix (ECM) remodelling is a poorly explored factor despite its established connection to gene expression via mechanotransduction that is linked to disease and drug resistance. ECM remodelling appears to occur randomly in space and time. In a mechanobiology context, biomaterials providing temporal or spatial variations is in its infancy. This project explores the idea that the degree of randomness of ECM remodelling relates to alterations in biological behaviour, thus contributing to disease development and providing analytic markers and therapeutic targets. In this project, a combined approach of experimental data generation through the development of new biomaterials, paired with computational and mathematical description of the interplay between random stimuli exposure and cell behaviour will provide new insight in the origin, prevention and management of diseases.