Understanding the role of axillary corynebacteria in thioalcohol-mediated odour production

人类体味的产生是腋下(腋窝)共生细菌活动的结果，这些细菌作用于我们大汗腺的无味分泌物。联合利华之前在实验室中的工作导致发现人葡萄球菌是硫醇BO成分的关键生产者。然而，在相同的利基环境中，有一些细菌被认为可以产生相同的气味，包括不同的棒状细菌。这个项目将通过继续调查参与硫醇生产的关键转运蛋白和酶的结构和生化特性，并开始梳理我们在这一过程中腋下微生物区系不同成分之间的潜在协同作用，来研究这些不同的细菌在硫醇生产中的作用。

The production of body odour in humans is the result of the activity of commensal bacteria in the underarm (axilla) working on odourless secretions from our apocrine glands. Previous work in the lab with Unilever led to the discovery of Staphylococcus hominis as being a key producer of the thioalcohol BO component. However, there are bacteria in the same niche that have been proposed to create the same odours including different Corynebacteria. This project will examine the role of these different bacteria in thioalcohol production by continuing to investigate the structural and biochemical properties of key transporters and enzymes involved in the process and start to tease our potential synergies between different components of the axilla microbiota in this process.