Understanding the role of axillary corynebacteria in thioalcohol-mediated odour production

了解腋窝棒状杆菌在硫醇介导的气味产生中的作用

• 批准号: 2607376
• 金额: --
• 依托单位: University of York
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2607376
• 关键词: Understanding; role; axillary; corynebacteria; thioalcohol

The production of body odour in humans is the result of the activity of commensal bacteria in the underarm (axilla) working on odourless secretions from our apocrine glands. Previous work in the lab with Unilever led to the discovery of Staphylococcus hominis as being a key producer of the thioalcohol BO component. However, there are bacteria in the same niche that have been proposed to create the same odours including different Corynebacteria. This project will examine the role of these different bacteria in thioalcohol production by continuing to investigate the structural and biochemical properties of key transporters and enzymes involved in the process and start to tease our potential synergies between different components of the axilla microbiota in this process.

人体体味的产生是腋下（腋窝）的细菌活动的结果，这些细菌作用于我们顶浆分泌腺的无味分泌物。之前与联合利华在实验室的工作导致发现人葡萄球菌是硫醇BO组分的主要生产者。然而，在相同的生态位中有一些细菌被提议产生相同的气味，包括不同的棒状杆菌。该项目将通过继续研究参与该过程的关键转运蛋白和酶的结构和生化特性来研究这些不同细菌在硫醇生产中的作用，并开始梳理腋窝微生物群不同组分之间的潜在协同作用。