Molecular assembly of the non-canonical inflammasome

非典型炎症小体的分子组装

• 批准号: 2607684
• 金额: --
• 依托单位: University of York
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2607684
• 关键词: Molecular; assembly; non; canonical; inflammasome

Your body is constantly targeted by pathogens like Salmonella, a food-borne pathogen. Immune cells recognize and protect your body against infectionsusing a detection platform called the inflammasome. We recently identified a novel protein sensor that enable the detection of Gram-negative bacteria toassemble a novel inflammasome complex called the non-canonical inflammasome. This exciting Ph.D. project will aim to understand thenon-canonical inflammasome is assembled and signal upon detection of bacteria. This project provides an outstanding training opportunity that combinebiochemistry, immunology, bacteriology and microscopy. You will be train to use techniques such as genetic engineering of cells, microscopy, flowcytometry, protein expression, cellular immunology techniques and biochemical characterization of protein interactions. The graduate skills training through lab meetings, seminars, conferences, and outreach activities will help you develop a broad range of scientific and transferable skill in a highly supportive environment. The project is suitable for applicants with strong interest in biochemistry, immunology and microbiology ready to tackle a challenging but rewarding project.

你的身体经常受到沙门氏菌等病原体的攻击，这是一种食源性病原体。免疫细胞通过一种叫做炎性小体的检测平台识别并保护你的身体免受感染。我们最近发现了一种新的蛋白质传感器，能够检测革兰氏阴性菌组装一种新的炎性小体复合物，称为非典型炎性小体。令人兴奋的博士学位。该项目旨在了解非规范炎性小体的组装和检测细菌时的信号。该项目提供了一个出色的培训机会，结合生物化学，免疫学，细菌学和显微镜。您将接受培训，以使用细胞遗传工程，显微镜，流式细胞术，蛋白质表达，细胞免疫学技术和蛋白质相互作用的生化表征等技术。通过实验室会议，研讨会，会议和推广活动的研究生技能培训将帮助您在高度支持的环境中发展广泛的科学和可转移技能。该项目适合对生物化学，免疫学和微生物学有浓厚兴趣的申请人，准备应对具有挑战性但有价值的项目。