Molecular assembly of the non-canonical inflammasome

你的身体经常受到沙门氏菌等病原体的攻击，沙门氏菌是一种食源性病原体。免疫细胞使用一种名为炎症小体的检测平台识别并保护你的身体免受感染。我们最近发现了一种新的蛋白质传感器，它能够检测革兰氏阴性细菌组装一种新的炎症体复合体，称为非典型性炎症体。这个令人兴奋的博士项目将致力于了解非规范炎症小体是如何组装的，并在检测到细菌时发出信号。该项目提供了一个将生物化学、免疫学、细菌学和显微镜相结合的绝佳培训机会。你将被训练使用细胞基因工程、显微镜、流式细胞术、蛋白质表达、细胞免疫学技术和蛋白质相互作用的生物化学表征等技术。通过实验室会议、研讨会、会议和外展活动进行的研究生技能培训将帮助您在高度支持的环境中发展广泛的科学和可转移技能。该项目适合对生物化学、免疫学和微生物学有浓厚兴趣的申请者，准备应对一个具有挑战性但有回报的项目。

Your body is constantly targeted by pathogens like Salmonella, a food-borne pathogen. Immune cells recognize and protect your body against infectionsusing a detection platform called the inflammasome. We recently identified a novel protein sensor that enable the detection of Gram-negative bacteria toassemble a novel inflammasome complex called the non-canonical inflammasome. This exciting Ph.D. project will aim to understand thenon-canonical inflammasome is assembled and signal upon detection of bacteria. This project provides an outstanding training opportunity that combinebiochemistry, immunology, bacteriology and microscopy. You will be train to use techniques such as genetic engineering of cells, microscopy, flowcytometry, protein expression, cellular immunology techniques and biochemical characterization of protein interactions. The graduate skills training through lab meetings, seminars, conferences, and outreach activities will help you develop a broad range of scientific and transferable skill in a highly supportive environment. The project is suitable for applicants with strong interest in biochemistry, immunology and microbiology ready to tackle a challenging but rewarding project.