Template Synthesis of Recognition-Encoded Oligomers

识别编码寡聚物的模板合成

• 批准号: 2607900
• 金额: --
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2607900
• 关键词: Template; Synthesis; Recognition; Encoded; Oligomers

The project will take concepts from Molecular Biology and apply them to the Organic Chemistry of a new class of molecules. The unique properties of nucleic acids have made them the material of choice for complex nanofabrication. High fidelity formation of duplexes via non-covalent interactions between complementary sequences provides a straightforward approach to molecular programming of multicomponent self-assembly and template synthesis. The structure of the nucleic acid backbone and bases can be changed without destroying these properties, suggesting that there are all kinds of unexplored organic molecules that will also show sequence selective duplex formation. This project will explore the synthesis of new oligomeric molecules equipped with defined sequences of recognition sites. The aim is to establish protocols for using one oligomer to template the synthesis of a copy of the same or reciprocal sequence. This template chemistry will provide tools for polymerisation of conventional monomers using templates to determine the sequence of recognition sites and hence incorporate the selective recognition properties of nucleic acids into new systems that have the potential for replication and evolution.

该项目将采用分子生物学的概念，并将其应用于一类新分子的有机化学。核酸的独特性质使其成为复杂纳米制造的首选材料。通过互补序列之间的非共价相互作用，高保真地形成双链，为多组分自组装和模板合成的分子编程提供了一种直接的方法。核酸主链和碱基的结构可以改变而不破坏这些性质，这表明存在各种未开发的有机分子也会表现出序列选择性双相形成。本项目将探索合成具有确定的识别位点序列的新低聚分子。目的是建立使用一种低聚物模板合成相同或互惠序列的副本的协议。这种模板化学将为传统单体的聚合提供工具，使用模板来确定识别位点的序列，从而将核酸的选择性识别特性纳入具有复制和进化潜力的新系统。