Synthesis and Study of Dynamic Halogen Bonding [1]Rotaxanes for Anion Recognition and Sensing

用于阴离子识别和传感的动态卤素键合[1]轮烷的合成和研究

• 批准号: 2124661
• 金额: --
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2124661
• 关键词: Synthesis; Study; Dynamic; Halogen; Bonding

The current topic of my research project is the synthesis and study of dynamic halogen bonding [1]rotaxanes for anion recognition and sensing. This project falls within the EPSRC physical science research theme and synthetic supramolecular chemistry research area. As part of the Beer Research Group at the University of Oxford, I am working towards increasing the understanding of molecular recognition processes in biological systems in order to be able to produce new molecular sensors, switches and devices. The objectives of my research project are to construct molecular lasso-type [1]rotaxanes which upon anion recognition are designed to undergo extended and contracted translational dynamic shuttling behaviour. This involves the synthesis of novel compounds as well as using NMR, UV-visible, fluorescence and electrochemical techniques in order to study the interlocked structure and the dynamic shuttling behaviour upon anion recognition. A further objective is the modification of a [1]rotaxane in order to make it operational in water. Interlocked molecules are being studied as host systems for anion recognition due to their unique structures containing three dimensional cavities which can bind complementary anions with high affinity. Combining small molecule recognition with molecular motion further explores the exciting potential nanotechnological applications of such interlocked system as molecular machines. Anion sensors are of great interest due to the importance of anions in a range of biological processes, which opens up a whole new range of potential applications. Such applications would require the system to function in an aqueous environment. Part of the research project could therefore involve the modification of a [1]rotaxane in order for it to be soluble and stable in water. Halogen bonding is a type of intermolecular interaction that has been widely studied in solid state systems but is less understood for solution chemistry. However, electron rich anions are thought to have strong interactions with halogens and act as halogen-bonding acceptors. Using the anion as part of the halogen-bonding system could then allow it to template the formation of a [1]rotaxane. Halogen bonding has furthermore been successfully used in anion host systems, which are capable of operating in water. Despite the great interest in interlocked structures, examples of [1]rotaxanes are still rare especiallycompared to examples of [2]rotaxanes. A successful synthesis of a novel dynamic halogen bonding [1]rotaxane for anion recognition and sensing would therefore allow new insights into this class of interlocked structures and its potential applications.

我目前的研究课题是用于阴离子识别和传感的动态卤素键合轮烷的合成和研究。该项目属于EPSRC物理科学研究主题和合成超分子化学研究领域。作为牛津大学啤酒研究小组的一员，我正在努力增加对生物系统中分子识别过程的了解，以便能够生产新的分子传感器、开关和设备。我的研究项目的目标是构建分子套索型[1]轮烷，它在阴离子识别后被设计为经历延长和收缩的平移动态穿梭行为。这包括合成新的化合物，以及使用核磁共振、紫外-可见、荧光和电化学技术来研究互锁结构和阴离子识别时的动态穿梭行为。另一个目标是对[1]轮烷进行修饰，使其能够在水中运行。互锁分子作为阴离子识别的主体系统，由于其独特的结构包含三维空穴，可以高亲和力地结合互补阴离子而被研究。将小分子识别与分子运动相结合，进一步探索了分子机器等互锁系统的令人兴奋的潜在纳米技术应用。由于阴离子在一系列生物过程中的重要性，阴离子传感器引起了人们的极大兴趣，这开辟了一系列全新的潜在应用领域。这样的应用需要系统在水环境中运行。因此，研究项目的一部分可能涉及对轮烷进行修饰，以使其在水中可溶和稳定。卤素键是一种分子间相互作用，在固态体系中得到了广泛的研究，但在溶液化学中却知之甚少。然而，富含电子的阴离子被认为与卤素有很强的相互作用，并作为卤素键的受体。使用阴离子作为卤素键合系统的一部分，然后可以允许它作为形成[1]轮烷的模板。此外，卤素键合还成功地用于阴离子主体体系，这些体系能够在水中操作。尽管人们对互锁结构很感兴趣，但[1]轮烷的例子仍然很少，特别是与[2]轮烷相比。因此，一种用于阴离子识别和传感的新型动态卤素键合轮烷的成功合成将使人们对这类互锁结构及其潜在应用有新的见解。