Depression, Cortisol, & Interpersonal Interaction

抑郁症、皮质醇、

• 批准号: 7054974
• 负责人: GINETTE C BLACKHART
• 金额: $ 2.95万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-30 至 2007-08-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7054974
• 关键词: behavioral /social science research tag; clinical research; cortisol; depression; gender difference; hormone regulation /control mechanism; human subject; interpersonal relations; predoctoral investigator; psychological stressor; psychosocial separation; salivary glands; social behavior; university student

DESCRIPTION (provided by applicant): Social rejection predicts a wide range of psychological problems, including the development of depression. In addition, rejection by others appears to maintain and exacerbate depressive symptoms for depressed individuals. The mechanism(s) by which interpersonal rejection causes depression and exacerbates depressive symptoms, however, is currently unknown. The proposed study will therefore measure salivary cortisol before and after a social rejection paradigm to assess the level of psychological distress people experience subsequent to interpersonal rejection and how this might play a role in the development of depression. Specifically, this research aims to 1) determine if salivary cortisol increases in response to social rejection, 2) determine if depression modulates the relationship between social rejection and salivary cortisol, and 3) determine if women experience greater psychological distress than men in response to social rejection. It is hypothesized that 1) salivary cortisol will increase significantly following a social rejection, indicating the experience of psychological distress; 2) depressed individuals (BDI >= 16) will exhibit greater salivary cortisol secretion in response to social rejection than non-depressed individuals (BDI <=6), suggesting that depressed individuals are more sensitive to social rejection than non-depressed individuals; and 3) women will exhibit greater increases in salivary cortisol following rejection by others than will men, demonstrating that women experience greater psychological distress to social rejection.

描述(由申请人提供)：社会拒绝预示着一系列的心理问题，包括抑郁症的发展。此外，其他人的拒绝似乎会维持和加剧抑郁症患者的抑郁症状。然而，人际拒绝导致抑郁并加剧抑郁症状的机制(S)目前尚不清楚。因此，这项拟议的研究将测量社交拒绝范式前后的唾液皮质醇，以评估人们在人际拒绝后经历的心理痛苦程度，以及这可能在抑郁症的发展中发挥的作用。具体地说，这项研究的目的是1)确定社会拒绝是否会增加唾液皮质醇，2)确定抑郁是否调节了社会拒绝和唾液皮质醇之间的关系，3)确定女性在应对社会拒绝时是否经历了比男性更大的心理痛苦。假设1)社交拒绝后唾液皮质醇会显著增加，表明有心理困扰的经历；2)抑郁个体(BDI&>=16)在应对社会拒绝时会比非抑郁个体表现出更多的唾液皮质醇分泌(BDI&lt；=6)，这表明抑郁的个体比非抑郁个体对社会拒绝更敏感；3)女性在被他人拒绝后唾液皮质醇的增加幅度会比男性更大，这表明女性对社会拒绝的心理痛苦更大。