Melanopsin polymorphisms in seasonal affective disorder

季节性情感障碍中的黑视蛋白多态性

• 批准号: 6936325
• 负责人: KATHRYN A ROECKLEIN
• 金额: $ 2.63万
• 依托单位: HENRY M. JACKSON FDN FOR THE ADV MIL/MED
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-18 至 2007-08-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6936325
• 关键词: behavioral /social science research tag; behavioral genetics; circadian rhythms; clinical research; family genetics; genetic polymorphism; genetic screening; human genetic material tag; human subject; interview; major depression; nonvisual photoreceptor; photobiology; phototherapy; predoctoral investigator; psychobiology; questionnaires; seasonal affective disorder; visual pigments

DESCRIPTION (provided by applicant): The proposed research will determine whether variations in the gene for melanopsin are correlated with SAD. Melanopsin, a photopigment found in retinal cells projecting to the circadian clock and other brain areas, is implicated in non-visual responses to environmental light. Etiological models and treatment outcome research for SAD suggest that winter-time disruption of retinal light detection may underlie the pathology of SAD. If variations in melanopsin segregate with SAD, melanopsin and retinal light detection will be implicated in the pathology of SAD. Dispositional dysregulation of responsiveness to light cues may provide further research opportunities regarding the significance of melanopsin variants; the interplay between melanopsin, non-visual light detection, circadian rhythms, and SAD; and bio-behavioral issues in treatment development such as mechanistic factors behind the efficacy of bright light therapy. Specific aims are: (1) to determine if individuals with SAD have a higher prevalence of the identified variant in melanopsin compared to healthy volunteers, and (2) to determine if the melanopsin variant segregates with SAD diagnosis in family members.

描述（由申请人提供）：拟议的研究将确定黑视素基因的变异是否与SAD相关。黑视素，一种在视网膜细胞中发现的投射到生物钟和其他大脑区域的光色素，与对环境光的非视觉反应有关。SAD的病因模型和治疗结果研究表明，冬季视网膜光检测的中断可能是SAD病理的基础。如果黑视素的变异与SAD分离，黑视素和视网膜光检测将涉及SAD的病理。性格对光信号的反应失调可能为黑视素变异的意义提供进一步的研究机会；黑视素、非视觉光检测、昼夜节律和SAD之间的相互作用；以及治疗发展中的生物行为问题，如强光疗法疗效背后的机制因素。具体目的是：(1)确定SAD患者是否比健康志愿者具有更高的黑视素变异患病率，(2)确定黑视素变异是否与家庭成员的SAD诊断相分离。