Sociobiological Influences on Poststroke Immune Function

描述(申请人提供)：尽管中风后治疗取得了许多进展，但许多患者出现了免疫并发症，导致发病率和死亡率增加。有强有力的证据表明，中风后免疫系统会发生变化，特别是炎症，可以在脑缺血的病理生理学中发挥作用。目前的建议将研究缺血内和缺血后环境对免疫反应的影响。采用大脑中动脉闭塞(MCAO)方法诱导短暂性脑缺血。在实验性卒中后，迟发型超敏反应(DTH)检测、KLH抗体产生和创面愈合率将作为外周免疫功能的综合指标(目标1)。亲社会互动(目标2)和社会压力(目标3)对免疫措施的影响也将被研究。综上所述，拟议的研究将为研究中风对免疫功能的影响提供基础，并可能为缺血性事件后可能改善患者健康的治疗和治疗提供见解。

DESCRIPTION (provided by applicant): Despite many advances in post-stroke treatment, many patients develop immunological complications, which lead to increased morbidity and mortality. There is strong evidence that the immune system is altered following stroke, and that inflammation in particular, can play a role in the pathophysiology of cerebral ischemia. The current proposal will examine the effects of intraischemic and post-ischemic environment on immune response. Middle cerebral artery occlusion (MCAO) will be used to induce transient ischemia. Following experimental stroke, delayed-typehypersensitivity.( DTH) testing, KLH antibody production, and rate of wound healing willbe used as integrative measures of peripheral immune function (Aim 1). The influence of pro-social interactions (Aim 2) and social stress (Aim 3) on immune measures also will be examined. Taken together, the proposed studies will provide a foundation on which to study the effects of stroke on immune function and may provide insights into the treatments and therapies following an ischemic event that may improve the health of the patient.