Multisensory integration and attention

多感官整合和注意力

• 批准号: 7000017
• 负责人: CHRISTINA M KARNS
• 金额: $ 2.96万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7000017
• 关键词: adolescence (12-20); age difference; attention; auditory stimulus; behavioral /social science research tag; brain electrical activity; cerebral cortex; clinical research; electroencephalography; evoked potentials; human subject; neural information processing; neuropsychology; predoctoral investigator; sensory feedback; touch; visual stimulus; young adult human (21-34)

DESCRIPTION (provided by applicant): Convergent evidence from behavior, psychophysics, ERP, and fMRI in humans, as well as single unit studies in animals highlights the importance of interactions across sensory modalities. However, there is still controversy about how early multisensory stimuli converge. One view holds that sensory streams converge in polymodal cortices only after being processed by unimodal cortices. This view does not exclude the possibility of feedback to unimodal cortical areas but is in contrast to the view that early unimodal cortices are affected by multisensory stimuli directly. While there is evidence that multisensory stimuli affect early sensory cortices, it has not been demonstrated that attention to a specific modality modulates the timing and spatial extent of multisensory interactions directly in humans. The goal of this project is to delineate the neural underpinnings and influence of attention on multisensory integration. We predict that when attention is directed to a sensory modality, unimodal stimuli will be enhanced at early latencies consistent with the view that intermodal attention modulates early sensory processing in the cortex. Furthermore, we predict that synchronous auditory and visual multisensory stimuli will elicit larger neural responses at latencies reflecting early sensory processing and that scalp distributions and source localization analyses will indicate that this modulation is occurring early in cortical processing. Finally, we predict that attention to different sensory modalities will result in further enhanced multisensory activity to the attended modality.

描述（由申请人提供）：人类行为，心理物理学，ERP和FMRI的收敛证据以及动物的单一单位研究强调了跨感觉方式相互作用的重要性。但是，关于早期多感觉刺激的融合仍然存在争议。一种视图认为，仅在单峰皮层处理后，感觉流在多层皮质中收敛。这种观点并不排除反馈对单峰皮层区域的可能性，但与以下观点形成鲜明对比：早期的单峰皮层直接受到多感官刺激的影响。尽管有证据表明多感觉刺激会影响早期感觉皮层，但尚未证明对特定模态的关注可以调节人类中多感官相互作用的时间和空间范围。该项目的目的是描述神经基础和关注对多感官整合的影响。我们预测，当注意力转向感觉方式时，在早期潜伏期将增强单峰刺激，这是一致的，即跨模式注意调节皮质中的早期感觉处理。此外，我们预测同步听觉和视觉多感官刺激将在反映早期感觉处理的潜伏期中引起更大的神经反应，并且头皮分布和来源定位分析将表明这种调节是在皮质处理的早期发生的。最后，我们预测，对不同感官方式的关注将导致进一步增强的多感官活动对参加的方式。