Multisensory integration and attention

多感官整合和注意力

• 批准号: 7111783
• 负责人: CHRISTINA M KARNS
• 金额: $ 2.45万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7111783
• 关键词: adolescence (12-20); age difference; attention; auditory stimulus; behavioral /social science research tag; brain electrical activity; cerebral cortex; clinical research; electroencephalography; evoked potentials; human subject; neural information processing; neuropsychology; predoctoral investigator; sensory feedback; touch; visual stimulus; young adult human (21-34)

DESCRIPTION (provided by applicant): Convergent evidence from behavior, psychophysics, ERP, and fMRI in humans, as well as single unit studies in animals highlights the importance of interactions across sensory modalities. However, there is still controversy about how early multisensory stimuli converge. One view holds that sensory streams converge in polymodal cortices only after being processed by unimodal cortices. This view does not exclude the possibility of feedback to unimodal cortical areas but is in contrast to the view that early unimodal cortices are affected by multisensory stimuli directly. While there is evidence that multisensory stimuli affect early sensory cortices, it has not been demonstrated that attention to a specific modality modulates the timing and spatial extent of multisensory interactions directly in humans. The goal of this project is to delineate the neural underpinnings and influence of attention on multisensory integration. We predict that when attention is directed to a sensory modality, unimodal stimuli will be enhanced at early latencies consistent with the view that intermodal attention modulates early sensory processing in the cortex. Furthermore, we predict that synchronous auditory and visual multisensory stimuli will elicit larger neural responses at latencies reflecting early sensory processing and that scalp distributions and source localization analyses will indicate that this modulation is occurring early in cortical processing. Finally, we predict that attention to different sensory modalities will result in further enhanced multisensory activity to the attended modality.

描述（由申请人提供）：来自人类行为、心理物理学、ERP和fMRI的趋同证据，以及动物的单单元研究，强调了跨感觉模式相互作用的重要性。然而，关于早期多感觉刺激是如何汇聚的，仍然存在争议。一种观点认为，感觉流只有经过单峰皮质处理后才会在多峰皮质中汇合。这种观点并不排除反馈到单峰皮质区域的可能性，但与早期单峰皮质直接受多感觉刺激影响的观点相反。虽然有证据表明多感觉刺激会影响早期感觉皮质，但尚未证明对特定模态的关注会直接调节人类多感觉相互作用的时间和空间范围。这个项目的目标是描绘神经基础和影响的多感觉整合的注意。我们预测，当注意力被引导到一个感觉模态时，单模态刺激将在早期潜伏期增强，这与多模态注意调节皮层早期感觉加工的观点一致。此外，我们预测同步的听觉和视觉多感觉刺激将在反映早期感觉加工的潜伏期引起更大的神经反应，头皮分布和源定位分析将表明这种调节发生在皮层加工的早期。最后，我们预测对不同感觉模态的关注将导致对被关注模态的多感觉活动进一步增强。