Extension of a two-stage genome-wide association study of endometrial cancer: validation of endometrial cancer risk-associated alleles and identification of ‘multiple-cancer’ risk loci

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Endometrial cancer (uterine/womb cancer) is the most common invasive gynaecological cancer in Australia. Each year more than 1400 women are affected by the condition. Our study is comparing genetic markers seen in patients to unaffected controls in an unbiased way to identify genetic factors that increase risk of this and other hormonal cancers, to better understand the causes of cancer. This will provide information for to help develop targeted therapies to prevent progression in the future.