Interdisciplinary strategies to uncover the missing enzymes and regulatory machinery in the biosynthesis of paclitaxel

揭示紫杉醇生物合成中缺失的酶和调节机制的跨学科策略

• 批准号: 2609198
• 金额: --
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2609198
• 关键词: Interdisciplinary; strategies; uncover; missing; enzymes

Plants produce a vast array of secondary metabolites that can be exploited for biomedicine. Since the 1940s 73% of anticancer drugs have been natural products and most of these trace their origins to plant sources (1). However, there in vitro chemical synthesis is routinely not commercially viable and the relevant biochemical pathways remain opaque. Further, the plant source may not be domesticated, is typically slow growing, with a limited population and the concentration of target molecules is routinely extremely low (2).

植物产生大量的次生代谢产物，可用于生物医学。自20世纪40年代以来，73%的抗癌药物是天然产物，其中大部分可追溯到植物来源（1）。然而，体外化学合成通常在商业上是不可行的，相关的生物化学途径仍然不透明。此外，植物来源可能不是驯化的，通常生长缓慢，种群有限，并且靶分子的浓度通常极低（2）。