NE Modulation of Olfactory Bulb During Learning in Mice

小鼠学习过程中嗅球的 NE 调节

• 批准号: 7057157
• 负责人: Wilder T Doucette
• 金额: $ 2.71万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7057157
• 关键词: action potentials; alpha adrenergic receptor; alpha antiadrenergic agent; behavior test; behavioral /social science research tag; beta adrenergic receptor; beta antiadrenergic agent; biological signal transduction; brain electrical activity; conditioning; laboratory mouse; learning; neural information processing; neurons; neuropsychology; norepinephrine; olfactions; olfactory lobe; psychopharmacology; sensory discrimination; single cell analysis

DESCRIPTION (provided by applicant): Our goal is to make a direct connection between noradrenaline (NE) modulation in the main olfactory bulb (MOB), changes in MOB network output, and behavior. We hypothesize that learning will induce, through NE, an overall increase in synchronization of mitral cell ensemble activity to the learned odor. We have preliminary evidence that complete blockade of NE signaling in the bulb impairs but does not impede an adult mouse's ability to discriminate between odor cues. We are currently characterizing the modulation occurring in olfactory bulb neuronal networks by recording from the mitral cell layer, the output neurons of the olfactory bulb, in awake-behaving mice engaged in an olfactory discrimination task. Finally, we will determine whether blockade of NE signaling will impair the changes in mitral cell activity observed during behavior.

描述（由申请人提供）：我们的目标是在主嗅球（MOB）中的去甲肾上腺素（NE）调节、MOB 网络输出的变化和行为之间建立直接联系。我们假设学习将通过 NE 诱导二尖瓣细胞群活动与习得气味的同步性总体增加。我们有初步证据表明，完全阻断球茎中的 NE 信号传导会损害但不会妨碍成年小鼠区分气味线索的能力。我们目前正在通过记录参与嗅觉辨别任务的清醒小鼠的二尖瓣细胞层（嗅球的输出神经元）来表征嗅球神经元网络中发生的调节。最后，我们将确定 NE 信号传导的阻断是否会损害行为过程中观察到的二尖瓣细胞活性的变化。