NE Modulation of Olfactory Bulb During Learning in Mice

描述（由申请人提供）：我们的目标是在主嗅球（MOB）中的去甲肾上腺素（NE）调制，MOB网络输出的变化和行为之间建立直接联系。我们假设，学习将通过NE诱导二尖瓣细胞集合活动与习得气味同步的整体增加。我们有初步的证据表明，完全阻断球茎中的NE信号会损害但不会阻碍成年小鼠区分气味线索的能力。我们目前正通过记录嗅球的输出神经元二尖瓣细胞层来描述在嗅球神经元网络中发生的调制，这些二尖瓣细胞层是在清醒行为的小鼠中进行嗅觉辨别任务的。最后，我们将确定NE信号的阻断是否会损害行为过程中观察到的二尖瓣细胞活性的变化。

DESCRIPTION (provided by applicant): Our goal is to make a direct connection between noradrenaline (NE) modulation in the main olfactory bulb (MOB), changes in MOB network output, and behavior. We hypothesize that learning will induce, through NE, an overall increase in synchronization of mitral cell ensemble activity to the learned odor. We have preliminary evidence that complete blockade of NE signaling in the bulb impairs but does not impede an adult mouse's ability to discriminate between odor cues. We are currently characterizing the modulation occurring in olfactory bulb neuronal networks by recording from the mitral cell layer, the output neurons of the olfactory bulb, in awake-behaving mice engaged in an olfactory discrimination task. Finally, we will determine whether blockade of NE signaling will impair the changes in mitral cell activity observed during behavior.