NE Modulation of Olfactory Bulb During Learning in Mice

我们的目标是在主要嗅球的去甲肾上腺素(NE)调制之间建立直接联系 (MOB)、MOB网络输出和行为的变化。我们假设学习会诱导，通过 NE，二尖瓣细胞团活动与习得气味的同步性总体增加。我们有 初步证据表明，完全阻断灯泡中的去甲肾上腺素信号会损害但不会阻碍 成年老鼠辨别气味线索的能力。我们目前正在对调制进行表征 通过从二尖瓣细胞层记录在嗅球神经元网络中发生的，输出神经元 觉醒的小鼠的嗅球参与了嗅觉辨别任务。最后，我们会 确定阻断NE信号是否会损害观察到的二尖瓣细胞活动变化 行为。

Our goal is to make a direct connection between noradrenaline (NE) modulation in the main olfactory bulb (MOB), changes in MOB network output and behavior. We hypothesize that learning will induce, through NE, an overall increase in synchronization of mitral cell ensemble activity to the learned odor. We have preliminary evidence that complete blockade of NE signaling in the bulb impairs but does not impede an adult mouse's ability to discriminate between odor cues. We are currently characterizing the modulation occurring in olfactory bulb neuronal networks by recording from the mitral cell layer, the output neurons of the olfactory bulb, in awake-behaving mice engaged in an olfactory discrimination task. Finally, we will determine whether blockade of NE signaling will impair the changes in mitral cell activity observed during behavior.