NE Modulation of Olfactory Bulb During Learning in Mice
NE Modulation of Olfactory Bulb During Learning in Mice
批准号:
7320264
负责人:
Wilder T Doucette
金额:
$2.71万
依托单位国家:
美国
项目类别:
财政年份:
2005
资助国家:
美国
项目状态:
已结题
起止时间:
2005-12-01 至 2009-11-30
关键词:
Action PotentialsAdrenergic AgonistsAdrenergic AntagonistsAdrenergic ReceptorAdultAnimalsAreaBehaviorBehavioralBrainCaregiversCell Culture SystemCellsCharacteristicsChemicalsComplexConditionCuesDataDiscriminationElectrodesFire - disastersGenomicsGoalsGray unit of radiation doseImpairmentIndividualLearningLinkMeasuresMemoryMolecularMusNeonatalNeuronsNorepinephrineNumbersOdorsOlfactory LearningOutputPaperPliabilityPopulationRattusRodentRoleSamplingSensory ProcessSignal TransductionSliceSpecificityStructureSumSystemTestingWorkawakebeanbehavior measurementbehavior testimplantationindium arsenideinsightlocus ceruleus structurenoradrenergicolfactory bulbpreferencepreventreceptorrelating to nervous systemresponse
中文摘要
我们的目标是在主要嗅球的去甲肾上腺素(NE)调制之间建立直接联系
(MOB)、MOB网络输出和行为的变化。我们假设学习会诱导,通过
NE,二尖瓣细胞团活动与习得气味的同步性总体增加。我们有
初步证据表明,完全阻断灯泡中的去甲肾上腺素信号会损害但不会阻碍
成年老鼠辨别气味线索的能力。我们目前正在对调制进行表征
通过从二尖瓣细胞层记录在嗅球神经元网络中发生的,输出神经元
觉醒的小鼠的嗅球参与了嗅觉辨别任务。最后,我们会
确定阻断NE信号是否会损害观察到的二尖瓣细胞活动变化
行为。
英文摘要
Our goal is to make a direct connection between noradrenaline (NE) modulation in the main olfactory bulb
(MOB), changes in MOB network output and behavior. We hypothesize that learning will induce, through
NE, an overall increase in synchronization of mitral cell ensemble activity to the learned odor. We have
preliminary evidence that complete blockade of NE signaling in the bulb impairs but does not impede an
adult mouse's ability to discriminate between odor cues. We are currently characterizing the modulation
occurring in olfactory bulb neuronal networks by recording from the mitral cell layer, the output neurons of
the olfactory bulb, in awake-behaving mice engaged in an olfactory discrimination task. Finally, we will
determine whether blockade of NE signaling will impair the changes in mitral cell activity observed during
behavior.
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NE Modulation of Olfactory Bulb During Learning in Mice
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批准号:7533459
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资助金额:$2.73万
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NE Modulation of Olfactory Bulb During Learning in Mice
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批准号:7057157
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项目类别:
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资助金额:$2.71万
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负责人:Wilder T Doucette
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依托单位:
NE Modulation of Olfactory Bulb During Learning in Mice
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批准号:7140732
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项目类别:
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资助金额:$2.71万
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财政年份:2005
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负责人:Wilder T Doucette
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依托单位:
海外基金