Renovation and expansion of BSL3 and ABSL3 facilities

BSL3和ABSL3设施的翻新和扩建

• 批准号: 7000878
• 负责人: ARTHUR H., M.B.B.CH. RUBENSTEIN
• 金额: $ 400万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-22 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7000878
• 关键词: biomedical facility; bioterrorism /chemical warfare; building /facility design /renovation

DESCRIPTION (provided by applicant): The University of Pennsylvania School of Medicine proposes to expand BSL3 laboratory capacity and to renovate an existing BSL2 vivarium, bringing it to BSL3 standards, to accommodate the rapid growth in NIHfunded research for emerging infectious diseases and biodefense that supports the work by a large number of Penn investigators. While both research and vivarium space have been greatly expanded in recent years, construction of new BSL3 facilities have not kept pace with the unexpectedly rapid growth in research and research training on emerging infectious diseases and HIV at the School of Medicine. Penn investigators play a major role in the Middle Atlantic Regional Center of Excellence (RCE) for Biodefense and Emerging Infectious Diseases Research, hold an NIH training grant on Emerging Infectious Diseases, hold awarded research grants that support work on West Nile, SARS, Ebola, Yersiniapestis, Anthrax, Crimean Congo Hemorrhagic fever virus and poxviruses, and have grants to support work on emerging infectious agents. Research at Penn on emerging infectious diseases and, to a lesser extent HIV, is greatly constrained by limited BSL3 capacity. There is only a single, common use BSL3 laboratory at the School of Medicine. This facility opened in 2000, and has been overwhelmed by large numbers of users. In addition, there is not a single animal BSL3 (ABSL3) facility at Penn. As a result, Penn investigators cannot perform small animal studies with BSL3 agents. To make it possible for Penn investigators to continue to expand their work on emerging infectious agents, biodefense and HIV, we propose to construct a new 500 sq. ft. BSL3 laboratory, renovate and double the size of our major BSL3 facility, and convert an ABSL2 into a modern ABSL3 facility.

描述（由申请人提供）： 宾夕法尼亚大学医学院提议扩大BSL 3实验室容量，并翻新现有的BSL 2动物园，使其达到BSL 3标准，以适应NIH资助的新兴传染病和生物防御研究的快速增长，这些研究支持了大量宾夕法尼亚大学研究人员的工作。虽然近年来研究和动物园空间都得到了极大的扩展，但新的BSL 3设施的建设并没有跟上医学院新兴传染病和艾滋病毒研究和研究培训的意外快速增长。宾夕法尼亚大学的研究人员在中大西洋地区卓越中心（RCE）的生物防御和新兴传染病研究中发挥着重要作用，拥有NIH关于新兴传染病的培训补助金，拥有支持西尼罗河，SARS，埃博拉，耶尔森氏菌，炭疽，克里米亚刚果出血热病毒和痘病毒工作的研究赠款，并有赠款支持新兴传染病的工作。宾夕法尼亚大学对新出现的传染病的研究，以及在较小程度上对艾滋病毒的研究，受到有限的BSL 3能力的极大限制。只有一个单一的，共同使用的BSL 3实验室在医学院。该设施于2000年启用，但由于用户众多而不堪重负。此外，Penn没有一个动物BSL 3（ABSL 3）机构。因此，宾夕法尼亚大学的研究人员无法使用BSL 3药物进行小动物研究。为了使宾夕法尼亚大学的研究人员能够继续扩大他们在新出现的传染性病原体、生物防御和艾滋病毒方面的工作，我们建议建造一个新的500平方米的实验室。英尺BSL 3实验室，翻新并扩大我们的主要BSL 3设施的规模，并将ABSL 2转换为现代化的ABSL 3设施。