Animal Core Facilities Addition/Renovation

动物核心设施增建/翻新

• 批准号: 6949839
• 负责人: SUSAN L SWAIN
• 金额: $ 342.99万
• 依托单位: TRUDEAU INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-19 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6949839
• 关键词: animal colony; biohazard control; biomedical facility; bioterrorism /chemical warfare; building /facility design /renovation; communicable diseases; flow cytometry; health science research; immunity; laboratory mouse; molecular biology

DESCRIPTION (provided by applicant): In response to PAR-04-122, Trudeau Institute submits a revised proposal to request matching funds to expand and improve its research core facilities. Trudeau Institute is a small, not-forprofit research institute focused on identifying mechanisms that regulate immunity to infectious disease, autoimmunity and cancer in young and aged individuals. The research aims of Trudeau investigators directly address the national goals of improving human health and increasing our ability to respond to emerging infectious diseases and bioterrorist threats. Trudeau Institute is part of a Regional Center of Excellence for Biodefense research and holds numerous PHS grants, totaling almost $7,000,000 in direct costs. Research at Trudeau Institute is dependent on state-of-the-art core facilities, including the Animal, Molecular Biology, Flow Cytometry and Animal Technical Services cores. However, these cores must be expanded and improved to meet the current and future research needs of the investigators. For example, the ABSL-2 and ABSL-3 facilities are 40 years old and require major updating and expansion. In addition, the Molecular Biology, Flow Cytometry and Animal Technical Services cores need to be consolidated and expanded. Therefore, we propose to construct a new building that will house mice requiring ABSL-2 (Aim 1), ABSL-3 (Aim 2) or quarantine level containment (Aim 3). The new building will also provide animal facility infrastructure and equipment needed to conduct infectious disease research (Aim 4). Finally, we propose to renovate the space currently used for housing infected animals in order to provide expanded, consolidated and contiguous space for the Molecular Biology, Flow Cytometry and the Animal Technical Services Cores (Aim 5).

描述（由申请人提供）： 为了响应04-122 par-par-par-trudeau Institute提交了一项修订的建议，要求匹配资金以扩展和改善其研究核心设施。特鲁多研究所（Trudeau Institute）是一家小型的非营利性研究所，致力于识别调节年轻人和老年人的传染病，自身免疫和癌症的机制。特鲁多调查人员的研究目的直接解决了改善人类健康的国家目标，并提高了我们对新兴的传染病和生物恐怖主义威胁的反应能力。特鲁多研究所（Trudeau Institute）是生物防腐研究卓越卓越中心的一部分，并持有大量的PHS赠款，总计近7,000,000美元的直接费用。特鲁多研究所的研究取决于最新的核心设施，包括动物，分子生物学，流式细胞仪和动物技术服务核心。但是，必须扩大和改进这些核心，以满足调查人员的当前和未来研究需求。例如，ABSL-2和ABSL-3设施已有40年的历史，需要进行重大更新和扩展。此外，需要巩固和扩展分子生物学，流式细胞仪和动物技术服务核心。因此，我们建议建造一座新建筑物，该建筑物将容纳需要ABSL-2（AIM 1），ABSL-3（AIM 2）或隔离水平遏制（AIM 3）的老鼠。新建筑还将提供进行传染病研究所需的动物设施基础设施和设备（AIM 4）。最后，我们建议翻新目前用于住房感染动物的空间，以便为分子生物学，流式细胞仪和动物技术服务核心提供扩展，巩固和连续的空间（AIM 5）。