Pregnanolone's effects in DBA/2J and C57BL/6J mice

孕烯醇酮对 DBA/2J 和 C57BL/6J 小鼠的影响

• 批准号: 6938386
• 负责人: ERIN E SHANNON
• 金额: $ 4.08万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-15 至 2006-01-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6938386
• 关键词: alcoholism /alcohol abuse; androgens; behavior test; behavioral /social science research tag; dizocilpine; drug receptors; ethanol; excitatory aminoacid; gamma aminobutyrate; hormone regulation /control mechanism; inhibitor /antagonist; laboratory mouse; midazolam; neuropsychology; operant conditionings; phencyclidine; predoctoral investigator; pregnanolone; psychopharmacology; serotonin; substance abuse related behavior

DESCRIPTION (provided by applicant): Neurosteroids represent a novel class of endogenous compounds that have the ability to exert rapid, nongenomic effects and produce various endocrine and behavioral effects. The role of these steroids in the behavioral effects of ethanol has received much recent attention. In the behavioral assay of drug discrimination, neurosteroids such as allopregnanolone and pregnanolone produce discriminative stimuli that are very similar to ethanol. These behavioral effects of neurosteroids need to be thoroughly examined to understand the role of these endogenous compounds in ethanol's actions. Drug discrimination is commonly used to identify candidate receptor mechanisms underlying the behavioral effects of drugs. This research proposal aims to extensively characterize the behavioral effects of pregnanolone through drug discrimination in DBA/2J and C57BL/6J inbred mice. Also, this research for the first time will compare the discriminative stimulus effects of pregnanolone with the motor effects of pregnanolone on schedule-controlled behavior to obtain an adequate picture of the subjective and motor behavioral effects of the neurosteroid pregnanolone.

描述（由申请人提供）：神经类固醇是一类新型的内源性化合物，具有发挥快速、非基因组效应和产生各种内分泌和行为效应的能力。这些类固醇在乙醇的行为效应中的作用最近受到了很多关注。在药物鉴别的行为试验中，神经类固醇如异孕酮和孕酮产生与乙醇非常相似的鉴别刺激。神经类固醇的这些行为效应需要彻底研究，以了解这些内源性化合物在乙醇作用中的作用。药物鉴别通常用于识别潜在药物行为效应的候选受体机制。本课题旨在通过对DBA/2J和C57BL/6J近交小鼠的药物鉴别，广泛表征孕酮类药物对小鼠行为的影响。此外，本研究将首次比较孕酮酮对计划控制行为的判别刺激效应和运动效应，以充分了解神经类固醇孕酮酮的主观和运动行为效应。