PLATELET, SHEAR STRESS, AND ARTERIAL THROMBOSIS

这项建议是建立一个专门的研究中心，在止血和血栓性疾病在得克萨斯州医学中心，总部设在贝勒医学院，休斯敦。该提案集中于动脉血栓形成的过程，开始于由血小板糖蛋白（GP）Ib-IX-V复合物和内皮下血管性血友病因子（vWF）介导的血小板粘附的初始步骤，并最终形成纤维蛋白交联血栓，其可能完全闭塞血管并引起组织梗死。除了检查血栓形成的基本机制外，我们还将研究两种临床疾病，一种是血栓形成的后果，血栓性微血管病，另一种是血栓形成并发症，外周动脉疾病。

This proposal is to establish a Specialized Center of Research in Hemostatic and Thrombotic Diseases in the Texas Medical Center, based at the Baylor College of Medicine, Houston. The proposal focuses on the process of arterial thrombosis, beginning with the initial step of platelet adhesion mediated by the platelet glycoprotein (GP) Ib-IX-V complex and subendothelial von Willebrand factor (vWF), and culminating in the formation of a fibrin cross-linked thrombus that may completely occlude a blood vessel and cause tissue infarction. In addition to examining basic mechanisms of thrombus formation, we will investigate two clinical disorders, one a consequence of thrombosis, the thrombotic microangiopathies, and one complicated by thrombosis, peripheral arterial disease.