PLATELET, SHEAR STRESS, AND ARTERIAL THROMBOSIS

该建议是在位于休斯顿贝勒医学院的德克萨斯医学中心建立一个止血和血栓性疾病专业研究中心。该建议侧重于动脉血栓形成的过程，从血小板糖蛋白（GP） Ib-IX-V复合物和内皮下血管性血液病因子（vWF）介导的血小板粘附的初始步骤开始，最终形成纤维蛋白交联血栓，可能完全阻塞血管并导致组织梗死。除了检查血栓形成的基本机制外，我们还将研究两种临床疾病，一种是血栓形成的后果，即血栓性微血管病变，另一种是血栓形成的并发症，即外周动脉疾病。

This proposal is to establish a Specialized Center of Research in Hemostatic and Thrombotic Diseases in the Texas Medical Center, based at the Baylor College of Medicine, Houston. The proposal focuses on the process of arterial thrombosis, beginning with the initial step of platelet adhesion mediated by the platelet glycoprotein (GP) Ib-IX-V complex and subendothelial von Willebrand factor (vWF), and culminating in the formation of a fibrin cross-linked thrombus that may completely occlude a blood vessel and cause tissue infarction. In addition to examining basic mechanisms of thrombus formation, we will investigate two clinical disorders, one a consequence of thrombosis, the thrombotic microangiopathies, and one complicated by thrombosis, peripheral arterial disease.