CORE--EPIDEMIOLOGY, DATA MANAGEMENT AND STATISTICS

核心——流行病学、数据管理和统计

• 批准号: 6827798
• 负责人: NICOLE SCHUPF
• 金额: $ 29.92万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6827798
• 关键词: biomedical facility; brain imaging /visualization /scanning; clinical research; computer data analysis; computer network; data collection methodology /evaluation; data management; disease /disorder proneness /risk; epidemiology; human subject; longitudinal human study; statistics /biometry

The Epidemiology, Database Management, and Statistics (EDMS) Core will provide the central epidemiologic, data management and biostatistical resources for the projects and other Cores. The EDMS Core will participate in Core-to-Core acitvities by weekly meetings with the other Core leaders and the the program coordinator to review and discuss all data-related issues, including cohort follow-up and retention, data completeness, and data retrival. The Core has three components. Data generated by each of the other cores and research projects will be transferred to the Database Component for entry and storage in an integrated SIR/DBMS data management system designed to meet all the needs of the program project with respect to cleaning, organization and retrieval of data for planned analyses. The activities of the Database Component will be carried out on a networked system of computers especially configured for data management operations. The Epidemiology Component will provide expert consultation in epidemiolgic methods, hypothesis testing, and in the interpretation and presentation of research findings. It will provide guidance on methodological issues such as subject classification on risk factor, outcome and related variables, development of derived variables, matching, bias and confounding. These activities will be carried out by means of bi-weekly meetings with Core statisticians and individual project investigators on a rotating basis and by a monthly joint meeting of project investigators to review manuscripts in preparation. The Statistics Component will be responsible for the planning and implementation of all analyses conducted by investigators. Core Statisticans, in collaboration with the Clinical and Brain Imaging Cores, will provide common summary outcome measures related to cognitive and functional performance, and to brain imaging results and will employ a core set of strategies for the analysis of large prospective multivariable and multivariate longitudinal datasets that pose common problems for the projects. By centralizing data management, epidemiological and statistical oversight in the EDMS Core, we will ensure the consistency and facilitate interaction of the projects with respect to uniform definitions of variables, data summarization, choice of tests, model building and interpretation of study results.

流行病学、数据库管理和统计（EDMS）核心将为项目和其他核心提供中心流行病学、数据管理和生物统计资源。EDMS核心将通过与其他核心负责人和项目协调员的每周会议参与核心对核心活动，以审查和讨论所有数据相关问题，包括队列随访和保留、数据完整性和数据检索。核心有三个组成部分。其他核心和研究项目生成的数据将传输到数据库组件，以便输入和存储在集成SIR/DBMS数据管理系统中，该系统旨在满足计划项目在清理、组织和检索数据以进行计划分析方面的所有需求。的活动 数据库部分将在专门为数据管理操作配置的计算机联网系统上进行。流行病学部分将提供流行病学方法，假设检验以及研究结果的解释和介绍方面的专家咨询。它将就方法学问题提供指导，如根据风险因素、结果和相关变量对受试者进行分类， 衍生变量、匹配、偏倚和混杂。开展这些活动的方式是，与核心统计员和项目调查员轮流举行双周会议，并每月举行项目调查员联席会议，审查编写中的文稿。统计部分将负责规划和执行调查员进行的所有分析。核心统计人员，与临床和 脑成像核心将提供与认知和功能表现以及脑成像结果相关的常见总结结果测量，并将采用一套核心策略来分析大型前瞻性多变量和多变量纵向数据集，这些数据集构成了项目的常见问题。通过将数据管理、流行病学和统计监督集中到EDMS核心，我们将确保一致性， 在变量的统一定义、数据汇总、测试选择、模型构建和研究结果解释方面，项目的相互作用。