Dual Pathway Models of ADHD: A High-Density ERP Study

ADHD 双通路模型：高密度 ERP 研究

• 批准号: 6957294
• 负责人: Kiesa Getz Kelly
• 金额: $ 4.73万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2006-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6957294
• 关键词: attention deficit disorder; behavior test; behavioral /social science research tag; bioimaging /biomedical imaging; brain imaging /visualization /scanning; clinical research; evoked potentials; human subject; impulsive behavior; middle childhood (6-11); motivation; neuropathology; postdoctoral investigator

DESCRIPTION (provided by applicant): Attention-Deficit/Hyperactivity Disorder (ADHD) is the most commonly diagnosed disorder of childhood, yet it is poorly understood. Dual pathway models of ADHD (e.g., Sonuga-Barke, 2003) postulate that both motivational and cognitive control dysfunction are prominent in ADHD, and that both are likely related to dysfunction of dopamine and overlapping thalamo-cortical-basal ganglia loops. Related to this model, there is preliminary evidence that motivational deficits and dysfunction of reward-punishment circuitry mediate cognitive control deficits in this population. In light of these theories and initial studies, it is the goal of the proposed study to employ high-density ERPs to examine the motivational impact of events in children with ADHD using the MFN ERP component, and to comprehensively evaluate, using both behavioral and ERP data, the potentially mediating role of motivation in ADHD-related cognitive control deficits. Specifically, it is predicted that ADHD-related behavioral deficits in cognitive control (i.e., response inhibition and error monitoring) and their ERP correlates (i.e., N2 and ERN) will normalize in the context of external motivators.

描述（由申请人提供）：注意力缺陷/多动障碍（ADHD）是儿童期最常见的诊断障碍，但人们对其了解甚少。ADHD的双途径模型（例如，Sonuga-Barke，2003）假设动机和认知控制功能障碍在ADHD中都很突出，并且两者都可能与多巴胺功能障碍和重叠的丘脑-皮质-基底神经节回路有关。与此模型相关，有初步证据表明，动机缺陷和奖惩回路功能障碍介导了这一人群的认知控制缺陷。根据这些理论和初步研究，这是拟议中的研究的目标，采用高密度ERP检查事件的动机影响ADHD儿童使用的MFN ERP组件，并全面评估，使用行为和ERP数据，潜在的中介作用的动机在ADHD相关的认知控制缺陷。具体地说，据预测，ADHD相关的认知控制行为缺陷（即，反应抑制和错误监控）和它们的ERP相关（即，N2和ERN）将在外部激励因素的背景下正常化。