Dual Pathway Models of ADHD: A High-Density ERP Study

描述（由申请人提供）：注意力缺陷/多动障碍（ADHD）是儿童最常见的诊断障碍，但对其了解甚少。ADHD的双通路模型（如Sonuga-Barke， 2003）假设动机和认知控制功能障碍在ADHD中都很突出，并且两者都可能与多巴胺功能障碍和重叠的丘脑-皮质-基底神经节回路有关。与该模型相关的是，有初步证据表明，动机缺陷和奖惩回路功能障碍介导了这一人群的认知控制缺陷。根据这些理论和初步研究，本研究的目标是使用高密度ERP来使用MFN ERP组件检查ADHD儿童事件的动机影响，并使用行为和ERP数据综合评估动机在ADHD相关认知控制缺陷中的潜在中介作用。具体而言，预测adhd相关的认知控制行为缺陷（即反应抑制和错误监测）及其ERP相关行为缺陷（即N2和ERN）在外部激励因素的作用下会正常化。

DESCRIPTION (provided by applicant): Attention-Deficit/Hyperactivity Disorder (ADHD) is the most commonly diagnosed disorder of childhood, yet it is poorly understood. Dual pathway models of ADHD (e.g., Sonuga-Barke, 2003) postulate that both motivational and cognitive control dysfunction are prominent in ADHD, and that both are likely related to dysfunction of dopamine and overlapping thalamo-cortical-basal ganglia loops. Related to this model, there is preliminary evidence that motivational deficits and dysfunction of reward-punishment circuitry mediate cognitive control deficits in this population. In light of these theories and initial studies, it is the goal of the proposed study to employ high-density ERPs to examine the motivational impact of events in children with ADHD using the MFN ERP component, and to comprehensively evaluate, using both behavioral and ERP data, the potentially mediating role of motivation in ADHD-related cognitive control deficits. Specifically, it is predicted that ADHD-related behavioral deficits in cognitive control (i.e., response inhibition and error monitoring) and their ERP correlates (i.e., N2 and ERN) will normalize in the context of external motivators.