Low Starch and Standard Food Pyramids for Weight Loss

低淀粉和标准减肥食物金字塔

• 批准号: 7124231
• 负责人: MICHAEL L DANSINGER
• 金额: $ 13.57万
• 依托单位: TUFTS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-21 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7124231
• 关键词: Low; Starch; Standard; Food; Pyramids

DESCRIPTION (provided by applicant): The purpose of this Mentored Patient-Oriented Research Career Award (K23) is to provide the investigator with additional training in clinical research methods for the dietary treatment and prevention of obesity and cardiovascular risk factors. The investigator is proposing a 5-year program composed of didactic and seminar-based training in nutrition research methodology, and a substantial, multifaceted research project of high clinical relevance. As US obesity prevalence continues to rise, the USDA food pyramid has faced increasing criticism from mainstream nutrition researchers and the general public. A growing body of evidence now suggests that a high refined starch or high glycemic load diet can exacerbate hunger, weight gain, and heart disease risk factors, particularly in the setting of insulin resistance and obesity. Public interest in moderate and low carbohydrate diets has escalated during the past 5 years, and a question of major public health importance is whether the US dietary guidelines and USDA food pyramid should continue to promote a starch-based diet. A clinical trial of popular diets recently reported by the investigator has contributed significantly to this debate. The proposed project has the following 3 specific aims: 1) To evaluate the effectiveness of low starch and standard versions of the USDA food pyramid for' -year weight loss and cardiac risk factor reduction under realistic clinical conditions in 200 overweight subjects. Outcomes will include body weight and composition, specialized lipoprotein assays, glucose, insulin, Creactive protein, and endothelial function assessed by brachial artery ultrasound in a subset of subjects. 2) To verify the logistical feasibility and number of subjects required for a large, multicenter trial comparing low starch versus standard USDA food pyramids for weight loss and cardiac risk reduction. 3) To determine dietary adherence rates, predictors of adherence, and the relationship between adherence and outcomes. This research is essential in order to support and strengthen current US dietary policy.

描述（由申请人提供）： 这项受过指导的以患者为导向的研究职业奖（K23）的目的是为研究人员提供有关临床研究方法的其他培训，以饮食治疗和预防肥胖和心血管危险因素。研究人员提出了一项为期5年的计划，该计划包括基于教学和研讨会的营养研究方法培训，以及一个高临床相关性的实质性，多方面的研究项目。随着美国肥胖症患病率的不断上升，美国农业部食品金字塔（USDA Food Pyramid）面临主流营养研究人员和公众的批评。现在，越来越多的证据表明，高精制淀粉或高血糖负荷饮食会加剧饥饿感，体重增加和心脏病危险因素，尤其是在胰岛素抵抗和肥胖的情况下。在过去的5年中，公众对中度和低碳水化合物饮食的兴趣一直在升级，而公共健康重要性的问题是，美国饮食指南和美国农业部食品金字塔是否应继续促进基于淀粉的饮食。研究者最近报道的一项流行饮食的临床试验为这场辩论做出了重大贡献。拟议的项目具有以下3个具体目标： 1）评估在200个超重受试者的现实临床条件下，低淀粉和USDA食品金字塔的标准版本的有效性减少了年度减肥和心脏风险因素。结果将包括体重和组成，专门的脂蛋白分析，葡萄糖，胰岛素，杂蛋白和内皮功能在受试者子集中通过臂动脉超声评估的内皮功能。 2）验证一项大型多中心试验所需的后勤可行性和受试者数量，比较低淀粉与标准USDA食品金字塔，以减轻体重和心脏风险减轻。 3）确定饮食依从性率，依从性的预测因素以及依从性与结果之间的关系。这项研究对于支持和加强当前的美国饮食政策至关重要。