Heart Rate Variability Response to CAM in Pediatrics

描述（由申请人提供）：中期职业研究者奖（K24）将为Kathi Kemper博士继续她在儿科补充和替代医学方面的开创性研究提供稳定的支持。她是《全科儿科医生》一书的作者，撰写了八篇普通和专业儿科教科书章节，并发表了70多篇同行评议的科学出版物。她也是NIH NLM资助项目的首席研究员，NIH- nccam资助的R25项目的现场首席研究员，并获得非NIH竞争性资助。她指导过许多研究生、研究员和初级教员。她是波士顿全人儿科教育和研究中心的首任主任。她是门诊儿科协会（APA）的前任主席，APA研究常务委员会的前任主席，以及美国儿科学会的现任成员。Kemper博士发起并联合主持了维克森林大学医学院（WFUSM）的生物能源研究委员会，并于2003-2004年为医科学生教授了一门关于治疗和愈合触摸的选修课。2003年，她进行了一项关于儿科肿瘤患者心率变异性（HRV）稳定性的初步研究；这项研究为未来研究这些患者对音乐和愈合触摸疗法的HRV变化提供了必要的数据。K24的三个项目包括：1)描述急性白血病儿童HRV与人口统计学、疾病和社会心理因素之间关系的横断面研究；2)一项前瞻性队列研究，评估音乐对同一人群HRV和心理状态的影响（包括急性和随后两次访问时额外“剂量”）；3)一项平行前瞻性队列研究，评估愈合触摸对同一人群这些结果的影响。所有这些研究都将为计划和实施这些疗法的随机对照试验提供关键数据。我们预计，Kemper博士和她的学员将根据本申请中提出的工作申请额外的NIH奖励。WFUSM和儿科部门高度支持Kemper博士的计划，这反映在多个部门和中心正在进行和计划的丰富的CAM研究，众多的支持信件和已经提交的研究资金申请中。K24奖项将使她从临床、教学和管理需求中解脱出来，并使她能够将时间和精力集中在本申请中描述的研究和指导活动上。

DESCRIPTION (provided by applicant): The Mid-Career Investigator award (K24) will provide stable support for Dr. Kathi Kemper to continue her seminal research in complementary and alternative medicine for pediatrics. She is the author of The Holistic Pediatrician, eight general and specialty pediatric textbook chapters, and over 70 peer-reviewed scientific publications. She is also the principal investigator on an NIH NLM- funded project, a site principal investigator on an NIH-NCCAM funded R25, and has non-NIH competitive funding. She has mentored many graduate students, fellows and junior faculty members. She initiated and was the first Director for the Center for Holistic Pediatric Education and Research in Boston. She is the past President of the Ambulatory Pediatric Association (APA), past Chair of the APA standing committee on Research, and a current member of the American Pediatric Society. Dr. Kemper initiated and co-chairs the Council on Bioenergetic Research at Wake Forest University School of Medicine (WFUSM), and in 2003-2004 taught an elective course for medical students on Therapeutic and Healing Touch. During 2003, she conducted a pilot study on the stability of heart rate variability (HRV) in pediatric oncology patients; this study provides essential data for future studies on changes in HRV in response to music and Healing Touch therapies for these patients. The three projects for the K24 include: 1) a cross-sectional study describing the relationship between HRV and demographic, disease and psychosocial factors in children with acute leukemia; 2) a prospective cohort study evaluating the effect of music on HRV and psychological state in the same population (both acutely and with additional "doses" at two subsequent visits); 3) a parallel prospective cohort study evaluating the effect of Healing Touch on these outcomes in the same population. All of these studies will provide data critical to planning and conducting randomized controlled trials of these therapies. We anticipate that Dr. Kemper and her mentees will apply for additional NIH awards based on the work proposed in this application. The WFUSM and the Department of Pediatrics are highly supportive of Dr. Kemper's plans, as reflected in the rich array of CAM research underway and planned in several departments and Centers, the numerous letters of support, and applications for research funding already submitted. The K24 award will free her from clinical, teaching and administrative demands, and allow her to focus her time and attention on research and mentoring activities described in this application.