MENTORED PATIENT-ORIENTED RESEARCH CAREER DEVELOPMENT AWARD

以患者为导向的研究职业发展奖

• 批准号: 7024988
• 负责人: JONATHAN S EMENS
• 金额: $ 12.98万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7024988
• 关键词: bioperiodicity; blindness; circadian rhythms; clinical research; electrocardiography; gene expression; genetic polymorphism; genetics; genotype; human subject; interview; patient oriented research; polymerase chain reaction; questionnaires; sleep; training; urinalysis

DESCRIPTION (provided by applicant): The goal of this study is to utilize recent developments in the molecular biology of circadian rhythms to better understand circadian functioning and circadian disorders in humans. The investigators will measure the endogenous circadian period (tau, the length of the biological day) in a unique population of 50 blind subjects that allows for very precise phenotyping. They will also tau phenotype 260 sighted subjects by measurement circadian phase and phase angle of entrainment. After tau phenotypes have been defined in each population, they will determine whether similar clock gene alleles predict phenotypes in the two populations. It is hypothesized that similar alleles predict diurnal preference and phase angle of entrainment in sighted subjects and circadian period in blind subjects. The candidate, Jonathan S. Emens, M.D., plans to become an independent investigator in the area of circadian physiology and genetics. He wishes to better understand the physiologic and genetic basis of diurnal preference in sighted humans and 24-hour sleep/wake schedule disorders in the blind. He plans to continue research into the basic mechanisms of the circadian system, illnesses with a circadian etiology and diseases impacted by circadian functioning. He plans to pursue a career in sleep medicine. Dr. Emens will be sponsored by Alfred J. Lewy, M.D., Ph.D., and Susan Hayflick, M.D., for this career development award. Under Dr. Lewy s guidance, Dr. Emens will expand his existing knowledge base in the area of circadian physiology and will receive training in techniques of human circadian research and the clinical impact of the circadian system. Dr. Hayflick will help Dr. Emens to develop an understanding of the theory and techniques of molecular genetics. In addition, Dr. Emens will complete a rigorous didactic program in molecular genetics and clinical research techniques. Coursework will be completed in biochemistry, molecular genetics, eukaryotic cell biology, molecular cell biology techniques, biostatistics, legal and ethical aspects of clinical research, scientific writing, randomized trial research and medical informatics.

描述（由申请人提供）： 本研究的目的是利用昼夜节律分子生物学的最新进展，以更好地了解人类的昼夜节律功能和昼夜节律紊乱。 研究者将在50名盲人受试者的独特人群中测量内源性昼夜节律周期（tau，生物日的长度），以进行非常精确的表型分析。 他们还将通过测量昼夜节律相位和相位角的夹带对260名视力正常的受试者进行tau表型。在每个群体中确定tau表型后，他们将确定相似的时钟基因等位基因是否预测两个群体中的表型。 据推测，相似的等位基因预测昼夜偏好和相位角的夹带在有视力的科目和昼夜周期的盲人科目。 候选人乔纳森·S。Emens，医学博士，计划成为昼夜生理学和遗传学领域的独立研究者。 他希望更好地了解有视力的人的昼夜偏好和盲人的24小时睡眠/觉醒时间表紊乱的生理和遗传基础。 他计划继续研究昼夜节律系统的基本机制，昼夜节律病因学疾病和受昼夜节律功能影响的疾病。 他计划从事睡眠医学方面的工作。 博士Emens将由Alfred J. Lewy医学博士赞助，哲学博士、和苏珊·海弗利克医学博士获得职业发展奖 在Lewy博士的指导下，Emens博士将扩大他在昼夜节律生理学领域的现有知识基础，并将接受人体昼夜节律研究技术和昼夜节律系统临床影响的培训。 Hayflick博士将帮助Emens博士发展对分子遗传学理论和技术的理解。 此外，Emens博士将完成分子遗传学和临床研究技术方面的严格教学计划。 课程将完成生物化学，分子遗传学，真核细胞生物学，分子细胞生物学技术，生物统计学，临床研究的法律的和伦理方面，科学写作，随机试验研究和医学信息学。