EFFECT OF MELATONIN ON HUMAN CIRCADIAN RHYTHMS

褪黑激素对人体昼夜节律的影响

基本信息

  • 批准号:
    3386908
  • 负责人:
  • 金额:
    $ 21.11万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1991
  • 资助国家:
    美国
  • 起止时间:
    1991-03-01 至 1994-02-28
  • 项目状态:
    已结题

项目摘要

Melatonin is a hormone produced by the pineal gland at night that may be involved in the natural regulation of circadian rhythms. Animal studies have shown that exogenous melatonin administration can synchronize "free- running" circadian rhythms and can accelerate the rate of adaptation to a new rest/activity cycle. In studies currently in progress, we administered melatonin orally to five totally blind subjects with free-running endogenous melatonin rhythms in an attempt to entrain them to a 24-hour day. Although entrainment did not result, melatonin treatment produced large phase advances in the endogenous melatonin rhythms. These advances are much more robust than when melatonin is given to sighted people, possibly because the competing time cues from the light-dark cycle are not present in the blind subjects. In this project, we will evaluate the constraining effects of the light- dark cycle by giving melatonin to both blind and sighted subjects. We will define the parameters that produce the maximal phase-advancing effects in both groups by varying the timing, dose and duration of melatonin administration. We will attempt to enhance the phase-advancing effects of exogenous melatonin administration by suppressing endogenous melatonin production with the drug atenolol will test the effects of melatonin in sighted subjects who are adapting to an abrupt advance of their sleep-wake cycle (a laboratory model of shift work adaptation). We will evaluate the phase-advancing effects of exogenous melatonin administration by measuring its effect on the timing (phase) of endogenous melatonin production by the pineal gland. Phase will be assessed by obtaining serial blood samples and measuring plasma melatonin concentrations to determine the precise "onset" of active production. An RIA will be employed for efficiently processing most of the samples but critical values around the time of the melatonin onset will be verified with a highly specific gas chromatographic negative ion mass spectrometric assay. These studies may lead to the use of melatonin as a way to treat both blind and sighted patients with abnormal circadian rhythms.
褪黑素是松果体在夜间产生的一种激素

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(1)

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ROBERT L SACK其他文献

ROBERT L SACK的其他文献

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{{ truncateString('ROBERT L SACK', 18)}}的其他基金

EXTRAOCULAR LIGHT EXPOSURE FOR CIRCADIAN DESYNCHRONY IN BLIND
盲人昼夜节律不同步的眼外光照射
  • 批准号:
    6571058
  • 财政年份:
    2001
  • 资助金额:
    $ 21.11万
  • 项目类别:
EXTRAOCULAR LIGHT EXPOSURE FOR CIRCADIAN DESYNCHRONY IN BLIND
盲人昼夜节律不同步的眼外光照射
  • 批准号:
    6571230
  • 财政年份:
    2001
  • 资助金额:
    $ 21.11万
  • 项目类别:
EXTRAOCULAR LIGHT EXPOSURE FOR CIRCADIAN DESYNCHRONY IN BLIND
盲人昼夜节律不同步的眼外光照射
  • 批准号:
    6465820
  • 财政年份:
    2000
  • 资助金额:
    $ 21.11万
  • 项目类别:
Minimal effective melatonin dose for circadian entrainment in blind people
盲人昼夜节律牵引的最小有效褪黑激素剂量
  • 批准号:
    6465881
  • 财政年份:
    2000
  • 资助金额:
    $ 21.11万
  • 项目类别:
MELATONIN FOR CIRCADIAN SLEEP DISORDERS IN THE BLIND
褪黑素治疗盲人昼夜节律睡眠障碍
  • 批准号:
    6465842
  • 财政年份:
    2000
  • 资助金额:
    $ 21.11万
  • 项目类别:
RELATIONSHIP OF AGE TO CIRCADIAN DESYNCHRONY IN PERMANENT NIGHT SHIFT WORK
长期夜班工作中年龄与昼夜节律不同步的关系
  • 批准号:
    6116938
  • 财政年份:
    1998
  • 资助金额:
    $ 21.11万
  • 项目类别:
MELATONIN FOR CIRCADIAN SLEEP DISORDERS IN THE BLIND
褪黑素治疗盲人昼夜节律睡眠障碍
  • 批准号:
    6116987
  • 财政年份:
    1998
  • 资助金额:
    $ 21.11万
  • 项目类别:
IDENTIFICATION OF FREE RUNNING RHYTHMS IN TOTALLY BLIND PEOPLE
全盲人自由跑步节奏的识别
  • 批准号:
    6116970
  • 财政年份:
    1998
  • 资助金额:
    $ 21.11万
  • 项目类别:
MELATONIN TREATMENT OF AGE RELATED INSOMNIA
褪黑激素治疗与年龄相关的失眠
  • 批准号:
    6116942
  • 财政年份:
    1998
  • 资助金额:
    $ 21.11万
  • 项目类别:
MELATONIN FOR CIRCADIAN SLEEP DISORDERS IN THE BLIND
褪黑素治疗盲人昼夜节律睡眠障碍
  • 批准号:
    6278182
  • 财政年份:
    1997
  • 资助金额:
    $ 21.11万
  • 项目类别:

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衰老过程中血管紧张素 (1-7) 和 β 肾上腺素受体信号传导
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