Factors affecting the conductance of GABA(A) channels

影响 GABA(A) 通道电导的因素

• 批准号: nhmrc : 179835
• 负责人: Peter Gage
• 金额: $ 27.12万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/factors-affecting-conductance-gabaa-channels/95745
• 关键词: Factors; affecting; conductance; GABA; channels

GABA(A) receptors provide most of the inhibition in the brain. If they are blocked, animals suffer from seizures and die. They are the target for a wide variety of medically useful drugs such as anaesthetics, tranquillisers such as valium and anti-epleptic drugs. All these drugs boost their effectiveness and increase inhibition in the brain. Most of them were discovered by chance. In this project, we will find out more about these receptors. This will give us more information about how the brain works and also help in the search for better, more selective drugs.

GABA(A)受体提供了大脑中大部分的抑制作用。如果它们被阻断，动物就会癫痫发作并死亡。它们是各种医学上有用的药物的目标，如麻醉剂、镇静剂，如安定和抗癫痫药物。所有这些药物都提高了它们的有效性，并增加了对大脑的抑制。他们中的大多数都是偶然发现的。在这个项目中，我们将更多地了解这些受体。这将给我们提供更多关于大脑如何工作的信息，也有助于寻找更好、更具选择性的药物。