Enhancing Translational Biomedical Research in Alaska.

描述（由申请人提供）：阿拉斯加土著健康研究中心（CANHR）与阿拉斯加西南部农村的Yup'ik爱斯基摩人社区合作开展健康差异研究。阿拉斯加费尔班克斯大学（UAF）代表CANHR和专业神经科学研究计划（ABNP），提议翻新费尔班克斯北极健康研究大楼（AHRB）的空地，以增加3600平方英尺的空间用于生物医学研究，并在阿拉斯加伯特利的Kuskokwim校区再增加1400平方英尺的空间。伯特利是56个爱斯基摩雅普人村庄的中心城市，我们在这些村庄进行健康差异研究。位于伯特利的育空-库斯科威姆校区靠近育空-库斯科威姆健康公司大楼和医院。我们有机会扩大我们的物理基础设施，并在生物医学研究中共同定位我们的智力资源，从而在UAF科学家与农村Yup'ik爱斯基摩社区（T1- t4）进行转化研究和UAF校园内的基础发现研究（T1）之间建立协同作用。增加的空间将积极影响我们在UAF开展更多临床导向研究的能力，并定期与我们在该地区工作了8年的阿拉斯加原住民农村研究伙伴和参与者进行交流。它将显著增加该州乃至全国经济最萧条的少数族裔社区之一的就业机会。具体目标1：在费尔班克斯校区的北极健康研究大楼（AHRB）翻新1566平方英尺的项目空间，创建一个综合临床和营养评估套件，旨在研究理解和消除爱斯基摩人之间的健康差异。具体目标2：建立项目空间为1899净ft2的电生理实验室，开展动物模型实验，旨在了解婴儿猝死综合征（SIDS）的病因和尼古丁对大脑的影响。具体目标3：改造我们在伯特利分校的一个空地，以建立一个与AHRB翻新平行的设施。它将增加参与者的参与，创造就业机会，并在育空-库斯科温地区建立研究能力。该设施将允许我们的研究人员在YK工作时在临床研究设施中面对面收集数据。意义：这个翻新的设施将增加对肥胖和慢性疾病的研究，以及在服务不足的社区中的其他健康差异。它将加强交流，传播研究成果，从实验室到社区的转化，并改善数据收集。

DESCRIPTION (provided by applicant): The Center for Alaska Native Health Research (CANHR) conducts health disparities research in partnership with Yup'ik Eskimo communities in rural Southwest Alaska. The University of Alaska Fairbanks (UAF), on behalf of CANHR and the Specialized Neuroscience Research Program (ABNP), proposes to renovate empty space in the Arctic Health Research Building (AHRB) in Fairbanks to add 3600 ft2 of space devoted to biomedical research, and another ~1400 ft2 on the Kuskokwim campus in Bethel, Alaska. Bethel is the hub city for the 56 Yup'ik Eskimo villages in which we conduct health disparities research. The Kuskokwim campus in Bethel is in close proximity to the Yukon-Kuskokwim Health Corporation building and hospital. The opportunity exists to expand our physical infrastructure and co-locate our intellectual resources in biomedical research to create a synergy between UAF scientists conducting translational research with rural Yup'ik Eskimo communities (T1-T4), and basic discovery bench research (T1) on the UAF campus. The increased space will positively impact our ability to conduct more clinically-oriented research at UAF and communicate regularly with our rural Alaska Native research partners and participants in the region in which we have worked for eight years. It will significantly increase jobs in one of the most economically depressed minority communities in the state and nation. The specific aims of our proposed research are: Specific Aim 1: To renovate a net of 1566 ft2 of program space in the Arctic Health Research Building (AHRB) on the Fairbanks campus to create an integrated clinical and nutritional assessment suite directed at research on understanding and eliminating health disparities among Yup'ik Eskimos. Specific Aim 2: To build an electrophysiology lab of 1899 net ft2 of program space to conduct experiments using animal models aimed at understanding the etiology of Sudden Infant Death Syndrome (SIDS) and the effects of nicotine on the brain. Specific Aim 3: To renovate an empty space at our branch campus in Bethel to build a facility that parallels the AHRB renovation. It will increase participant engagement, create jobs and build research capacity in the Yukon Kuskokwim (YK) region. This facility will allow our researchers to collect data face-to-face in a clinical research facility when working in the YK. Significance: This renovated facility will increase research on obesity and chronic diseases and other health disparities among an underserved community. It will enhance communication, dissemination of research results, translation from bench to community and improve data collection.