Initiative in Stem Cell Biology

干细胞生物学倡议

• 批准号: 7842919
• 负责人: GILBERT C. WHITE, II
• 金额: $ 293.27万
• 依托单位: VERSITI WISCONSIN, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-20 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7842919
• 关键词: American; Basic Science; Blood; Bone Marrow; Clinical Treatment; Faculty; Goals; Growth; Institution; Laboratories; Maintenance; Occupations; Pluripotent Stem Cells; Recruitment Activity; Research; Research Institute; Research Personnel; Source; Stem Cell Research; Stem cells; Therapy Clinical Trials; Translating; Wisconsin; design; human embryonic stem cell; member; peripheral blood; programs; square foot; stem cell biology

DESCRIPTION (provided by applicant): The overall goal of this application is to convert shelled space in BloodCenter of Wisconsin's Blood Research Institute (BRI) into finished laboratory space in order to grow the Stem Cell Program at the BRI. The objectives are to: 1) build-out the 7000 gross sq ft of shelled space into 4771 net sq ft of finished laboratory space consisting of 10 modules and adjacent alcoves and 1655 net sq ft associated core lab space; 2) relocate the laboratories of two established BRI investigators with stem cell research programs into the built-out laboratory space; 3) recruit up to five new faculty members with stem cell research programs into the built-out laboratory space; 4) create a Stem Cell Core Laboratory that will provide researchers at the BRI and neighboring institutions with a central source for human embryonic stem cells, inducible pluripotent stem cells (iPS), and stem cells obtained from peripheral blood or bone marrow for the purpose of furthering their research efforts; 5) create a "clean lab" that will support Good Manufacturing Practices (GMP) to provide stem cell-derived cellular therapies for clinical trials aimed at translating basic science discoveries into clinical treatments. The conversion of this space to finished research space will permit the concentration of stem cell researchers in a section of the building around core support facilities. It is also essential for the growth of the stem cell program to the size approved by the BCW Board of Directors. An integrated project team has been formed and plans are in place to construct this finished space using sustainable/green design considerations. The project can progress quickly thereby having an immediate impact on the creation and maintenance of American jobs.

描述（由申请人提供）：本申请的总体目标是将威斯康星州血液研究所（BRI）血液中心的外壳空间转换为成品实验室空间，以便在BRI发展干细胞计划。目标是：1)将7000平方英尺的外壳空间扩建为4771平方英尺的成品实验室空间，包括10个模块和相邻的凹室，以及1655平方英尺的相关核心实验室空间；2)将两名具有干细胞研究项目的BRI研究人员的实验室搬迁到已建成的实验室空间；3)招募最多5名具有干细胞研究项目的新教师到已建成的实验室空间；4)建立干细胞核心实验室，为“一带一路”和周边机构的研究人员提供人类胚胎干细胞、诱导多能干细胞（iPS）和从外周血或骨髓中获得的干细胞的中心来源，以进一步推进他们的研究工作；5)建立一个“洁净实验室”，支持良好生产规范（GMP），为临床试验提供干细胞衍生的细胞疗法，旨在将基础科学发现转化为临床治疗。将这个空间转换为完成的研究空间将允许干细胞研究人员集中在核心支持设施周围的一部分建筑中。这对于干细胞项目发展到BCW董事会批准的规模也是至关重要的。