Initiative in Stem Cell Biology

描述(由申请者提供)：本申请的总体目标是将威斯康星州血液研究所(BRI)血液中心的带壳空间改造为完成的实验室空间，以便在BRI发展干细胞计划。其目标是：1)将7000平方英尺的带壳空间扩建为4771平方英尺的已完工实验室空间，包括10个模块和相邻的凹室，以及1655平方英尺的相关核心实验室空间；2)将两名拥有干细胞研究项目的已有研究人员的实验室搬迁到已建成的实验室空间；3)将最多5名新的具有干细胞研究项目的教职员工招聘到已建成的实验室空间；4)创建干细胞核心实验室，为一带一路及周边机构的研究人员提供人类胚胎干细胞、可诱导多能干细胞(IPS)以及从外周血或骨髓中获取的干细胞的中心来源，以促进他们的研究工作；5)创建支持良好制造规范(GMP)的“清洁实验室”，为旨在将基础科学发现转化为临床治疗的临床试验提供干细胞衍生细胞疗法。将这个空间改造成完工的研究空间，将允许干细胞研究人员集中在建筑的核心支持设施周围的一部分。这对干细胞计划的发展到BCW董事会批准的规模也是至关重要的。 已经成立了一个综合项目小组，并计划利用可持续/绿色设计考虑来建造这个完工的空间。该项目进展迅速，从而对创造和维持美国就业机会产生立竿见影的影响。

DESCRIPTION (provided by applicant): The overall goal of this application is to convert shelled space in BloodCenter of Wisconsin's Blood Research Institute (BRI) into finished laboratory space in order to grow the Stem Cell Program at the BRI. The objectives are to: 1) build-out the 7000 gross sq ft of shelled space into 4771 net sq ft of finished laboratory space consisting of 10 modules and adjacent alcoves and 1655 net sq ft associated core lab space; 2) relocate the laboratories of two established BRI investigators with stem cell research programs into the built-out laboratory space; 3) recruit up to five new faculty members with stem cell research programs into the built-out laboratory space; 4) create a Stem Cell Core Laboratory that will provide researchers at the BRI and neighboring institutions with a central source for human embryonic stem cells, inducible pluripotent stem cells (iPS), and stem cells obtained from peripheral blood or bone marrow for the purpose of furthering their research efforts; 5) create a "clean lab" that will support Good Manufacturing Practices (GMP) to provide stem cell-derived cellular therapies for clinical trials aimed at translating basic science discoveries into clinical treatments. The conversion of this space to finished research space will permit the concentration of stem cell researchers in a section of the building around core support facilities. It is also essential for the growth of the stem cell program to the size approved by the BCW Board of Directors. An integrated project team has been formed and plans are in place to construct this finished space using sustainable/green design considerations. The project can progress quickly thereby having an immediate impact on the creation and maintenance of American jobs.