BASIC SCIENCE STUDIES ON GENE THERAPY OF BLOOD DISEASES

血液病基因治疗的基础科学研究

• 批准号: 2799137
• 负责人: Arun Srivastava
• 金额: $ 18.8万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2799137
• 关键词: BASIC; SCIENCE; STUDIES; GENE; THERAPY

This is a new application for a training program to support 6 postdoctoral trainees (M.D. and/or Ph.D.) and 6 predoctoral students (M.D./Ph.D.) per year with a strong emphasis on cell and molecular biology/immunology of gene therapy. The average training period for postdoctoral and predoctoral students will be 3 years and 4 years, respectively. Thirteen well-established preceptors will provide extensive training in highly active as well as interactive research laboratories pursuing state of the art research on fundamental aspects of cellular, molecular biological, and immunological aspects of a variety of human diseases, and the prospects of developing noel gene therapy approaches for some of these disorders. Most of the preceptors are housed in newly built or renovated spacious laboratories in the Department of Microbiology and Immunology; Division of Hematology/Oncology, Department of Medicine; Department of Medicinal and Molecular Genetics; Herman B Wells Center for Pediatric Research, Department of Pediatrics; and the Walther Oncology Center, in three adjoining buildings. Strong track-records of peer-reviewed publications and extramural funding of each of the preceptors a major strength of the proposed training program. Ample opportunities for pursuing multi- disciplinary research exist due to active, ongoing scientific collaborations among various preceptors. A significant emphasis is placed to promote and foster the development of the next generation of biomedical researchers committed to scientific careers in academic medicine to become independent investigators who, in turn, will themselves be productive and competitive. A multi-pronged approach for staff members and visiting scientists; formal and informal courses and seminars; laboratory meetings; and participation in state, national and international scientific meetings, is already in place and will be further emphasized. The decision to associate with a laboratory will be made by mutual consent of the trainee and the preceptor, and the scientific development of the trainee will be facilitated by a research committee composed of preceptors with multi-disciplinary research interests. Major resources that are available include internationally recognized clinical and basic science research programs, one of only three NIH-designated National Gene Vector Laboratories in the U.S., state of the art infrastructure, and frequent contacts with active investigators at Indiana University in Bloomington, Purdue University in West Lafayette, all in close proximity, and other investigators nationally as well as internationally.

这是一项新的培训计划申请，旨在支持6名博士后实习生(医学博士和/或博士)。博士后6人(医学博士/博士研究生)每年重点研究细胞和分子生物学/免疫学的基因治疗。博士后和博士后平均培养周期分别为3年和4年。13位著名的导师将在高度活跃和互动的研究实验室提供广泛的培训，这些实验室致力于各种人类疾病的细胞、分子生物学和免疫学方面的基本方面的研究，以及为其中一些疾病开发NOEL基因治疗方法的前景。大多数受赠者都被安置在新建或翻新的宽敞的实验室里，这些实验室包括微生物学和免疫学系；医学系血液/肿瘤科；医学和分子遗传学系；儿科赫尔曼·B·威尔斯儿科研究中心；以及毗邻三栋建筑的沃尔特肿瘤学中心。经过同行评审的出版物的良好记录和每位导师的外部资助是拟议培训方案的主要优势。由于不同研究人员之间积极、持续的科学合作，存在着大量从事多学科研究的机会。重点是促进和促进下一代生物医学研究人员的发展，他们致力于学术医学的科学事业，成为独立的研究人员，他们本身将具有生产力和竞争力。已经为工作人员和来访科学家、正式和非正式课程和研讨会、实验室会议以及参加国家、国家和国际科学会议采取了多管齐下的办法，并将进一步予以强调。与实验室合作的决定将在学员和导师双方同意的情况下做出，学员的科学发展将由一个由具有多学科研究兴趣的导师组成的研究委员会促进。可用的主要资源包括国际公认的临床和基础科学研究项目，美国仅有的三个由NIH指定的国家基因矢量实验室之一，最先进的基础设施，以及与位于布鲁明顿的印第安纳大学、位于西拉斐特的普渡大学的活跃调查人员以及其他国内外调查人员的频繁接触。