Construction of (A)BSL-3 Laboratory of Infectious Diseases at the University of S

描述（由申请人提供）：这是一个建议，以建立一个新的，独立的25,800平方英尺。南亚拉巴马大学（美国）的传染病实验室（LID）大楼，将容纳新的BSL-2、BSL-3和动物BSL-3（ABSL-3）实验室。需要新的空间来维持和支持现有的，完善的和高度重视的研究计划，以及为扩大计划提供空间，重点是对人类健康和安全构成重大威胁的选择代理病原体。拟议的设施将在功能上取代目前的BSL-3实验室大楼，分子生物学实验室（LMB）。LMB成立于1978年，容纳了微生物学和免疫学系的研究人员，他们对立克次氏体属的人类选择性病原体进行了资金充足的研究计划，最近扩大到包括伯克霍尔德氏菌选择性病原体。拟议的设施将解决与LMB有关的两个问题。首先，它将为研究人员提供单独的BSL-2和BSL-3实验室区域，通过允许使用适当的协议进行较低的密封研究，同时单独保持BSL-3级研究所需的较高密封条件，大大简化和加快研究的步伐。其次，它将通过提供动物BSL-3（ABSL-3）实验室为大学研究界提供关键的新资源，这些实验室对于评估宿主-病原体相互作用和测试与致病机制有关的假设以及开发新疗法和疫苗至关重要。该设施的建设将对美国的生物医学研究产生积极影响，加强研究竞争力，并获得支持美国就业的资金。LID将通过支持短期工程和建筑工作以及长期研究职位（包括教师、研究技术人员和学生）来刺激南部亚拉巴马地区的经济。

DESCRIPTION (provided by applicant): This is a proposal to construct a new, stand-alone 25,800 sqft. Laboratory of Infectious Diseases (LID) building at the University of South Alabama (USA) that will house new BSL-2, BSL-3, and animal BSL-3 (ABSL-3) laboratories. New space is needed to sustain and support existing, well-established, and highly-regarded research programs as well as to provide space for an expanding program focused on Select Agent pathogens that pose significant threats to human health and security. The proposed facility will functionally replace the current BSL-3 laboratory building, the Laboratory of Molecular Biology (LMB). The LMB, established in 1978, houses investigators of the Department of Microbiology and Immunology who conduct well-funded research programs on human Select Agent pathogens of the genus Rickettsia and has recently expanded to include Burkholderia Select Agent pathogens. The proposed facility will address two problems associated with the LMB. Firstly, it will provide separate BSL-2 and BSL-3 laboratory areas for the investigators, greatly simplifying and accelerating the pace of research by allowing lower containment studies to be conducted using appropriate protocols while separately maintaining the higher containment conditions required for BSL-3 level studies. Secondly, it will provide a critical new resource to the university research community by providing animal BSL-3 (ABSL-3) laboratories which are essential for evaluating host-pathogen interactions and for testing hypotheses related to pathogenic mechanisms and for the development of new therapies and vaccines. The construction of the facility will positively impact biomedical research at USA, strengthening research competitiveness and the acquisition of funds to support American jobs. The LID will stimulate the economy of the South Alabama region by supporting both short-term engineering and construction jobs as well as long term research positions including faculty, research technologists and students.