RNAi and Related Pathways

RNAi 和相关途径

• 批准号: 7001873
• 负责人: CRAIG C MELLO
• 金额: $ 1万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7001873
• 关键词: RNA interference; biological signal transduction; double stranded RNA; gene induction /repression; meeting /conference /symposium; travel

DESCRIPTION (provided by applicant): RNA silencing phenomena in a variety of plants, animals and fungi share a common underlying mechanism. At the heart of this mechanism lies ancient double-stranded RNA processing machinery that functions in RNA-based immunity, developmental gene regulation, transcriptional silencing and genomic stability. The aim of this meeting is to explore similarities and differences between these related pathways, to probe the underlying molecular mechanisms and to explore new methods for harnessing these mechanisms for gene discovery and therapeutics applications.

描述（由申请人提供）：多种植物、动物和真菌中的RNA沉默现象具有共同的潜在机制。 这种机制的核心是古老的双链RNA加工机制，它在基于RNA的免疫、发育基因调控、转录沉默和基因组稳定性中发挥作用。 本次会议的目的是探索这些相关途径之间的相似性和差异，探索潜在的分子机制，并探索利用这些机制进行基因发现和治疗应用的新方法。