FASEB SUMMER RESEARCH CONFERENCE: TRANSPORT ATPASES

FASEB 夏季研究会议：运输ATP酶

• 批准号: 7000990
• 负责人: ALAN E. SENIOR
• 金额: $ 1.5万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-15 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7000990
• 关键词: adenosinetriphosphatase; meeting /conference /symposium; membrane transport proteins; travel

DESCRIPTION (provided by applicant): This is an application for partial funding for the FASEB Summer Research Conference entitled "Transport ATPases: Genomics, Mechanisms, and Relevance to Diseases". The conference will be held at Vermont Academy, Saxtons River, Vermont, from July 16-21, 2005. The goal of the meeting is to bring together -150 participants in a secluded environment for five days of extensive scientific dialog. The Conference Program encompasses two Special Lectures, nine Sessions with 4 lectures each, 3 Poster Sessions, and one Young Investigator Forum. Topics to be presented in depth will be: Genomic survey of transport ATPases, relevance of transport ATPases to human diseases, structure and mechanism of V-ATPases, crystal structures and mechanism of Ca- and Na.K-ATPase, relevance of cation pumps to cardiac function and disease, crystal structures and mechanism of F-ATPase/ATP synthase, crystal structures and mechanism of ABC transporters, physiological relevance of ATPase isoforms, diverse roles of ABC transporters in disease, transport ATPases as nanomotors, and small protein regulators of P-type cation pumps. The Poster Sessions and Young Investigator Forum will foster communication between established and younger scientists; recruitment and active participation of women, minorities, and persons with disabilities will be emphasized. It is expected that the conference will be highly-significant with regard to both basic and medical sciences. Rapid recent progress in definition of crystal structures has advanced understanding of mechanisms and opens up avenues for computer modeling and drug development. Genomic surveys reveal an increasing number of transport ATPases and their linkage to genetic diseases. It is also clear that pathogenetic features of many more common disease states, such as heart failure and drug resistance, are related to altered expression or function of transport ATPases. This conference, focussed on transport ATPases but multidisciplinary in nature, is therefore very clearly related to the mission of NIH.

描述（由申请人提供）： 这是为 FASEB 夏季研究会议申请部分资助，题为“转运 ATP 酶：基因组学、机制和与疾病的相关性”。会议将于 2005 年 7 月 16 日至 21 日在佛蒙特州萨克斯顿河的佛蒙特学院举行。会议的目标是让 -150 名与会者在一个僻静的环境中进行为期五天的广泛科学对话。会议计划包括两场特别​​讲座、九场会议（每场 4 场讲座）、3 场海报会议和一场青年研究者论坛。深入展示的主题包括：转运ATP酶的基因组调查、转运ATP酶与人类疾病的相关性、V-ATP酶的结构和机制、Ca-和Na.K-ATP酶的晶体结构和机制、阳离子泵与心脏功能和疾病的相关性、F-ATP酶/ATP合酶的晶体结构和机制、ABC转运蛋白的晶体结构和机制、生理相关性 ATP 酶亚型、ABC 转运蛋白在疾病中的不同作用、作为纳米马达转运 ATP 酶以及 P 型阳离子泵的小蛋白调节剂。海报会议和青年研究者论坛将促进老牌科学家和年轻科学家之间的交流；将强调妇女、少数民族和残疾人的招募和积极参与。预计这次会议对于基础科学和医学科学都将具有非常重要的意义。晶体结构定义的最新进展促进了对机制的理解，并为计算机建模和药物开发开辟了途径。基因组调查揭示了转运 ATP 酶数量的增加及其与遗传疾病的联系。同样清楚的是，许多更常见疾病状态的发病特征，例如心力衰竭和耐药性，与转运 ATP 酶的表达或功能改变有关。这次会议的重点是运输 ATP 酶，但本质上是多学科的，因此与 NIH 的使命非常相关。