ASCB Summer Meeting: Coordinating the Events of Directed

描述（由申请人提供）：本次会议“定向细胞运动的系统集成”将由美国细胞生物学学会（ASCB）赞助。ASCB夏季会议的主题由ASCB成员提出，并由一个委员会根据组织者和潜在演讲者的重要性、及时性、兴趣和优势来选择。会议将于2005年7月27日至30日在华盛顿州西雅图的华盛顿大学举行。细胞的定向迁移涉及多种细胞信号、细胞骨架和粘附系统在自我延续循环中的复杂协调。在过去，细胞运动周期的许多系统在很大程度上是孤立研究的。这些劳动的成果建立了一个更广泛的知识基础，使这些分子系统之间的相互作用变得明显。因此，需要进一步鼓励理解这些细胞成分是如何整合和协调的。此外，已经有了很大的技术进步，这有助于我们在每个运动子系统的理解进步。对于一个目前准备高速发展的领域，至关重要的是，研究人员定期互动，讨论最近的进展与以前的范式和未来的发展。因此，我们组织了一次会议，鼓励这些领域研究的知识交流，目的是促进对细胞运动的机械和信号系统如何整合和协调的更全面的思考。会议将包括关于分子机制、生物物理学和信号转导的讨论，以及近年来在该领域取得重大进展的新开发技术的亮点。演讲将由受邀演讲者和从提交的摘要中选出的演讲者进行。后者将主要是年轻的研究人员，而前者将是有远见的人，在新的结果和一般观点之间进行平衡的演讲。海报会议将促进一对一的互动。

DESCRIPTION (provided by applicant): This meeting "Systems Integration in Directed Cell Motility" will be sponsored by the American Society of Cell Biology (ASCB). Topics of ASCB summer meetings are proposed by ASCB members and selected by a committee based on significance, timeliness, interest, and strengths of the organizers and potential speakers. The meeting will be held at the University of Washington, Seattle, WA on July 27-30, 2005. The directed migration of cells involves the complex coordination of multiple cellular signaling, cytoskeletal and adhesion systems in a self-perpetuating cycle. In the past, many of the systems of the cell motility cycle have, in large part, been studied in isolation. The fruits of these labors have established a broader knowledge base, making cross-talk between these molecular systems evident. As such, understanding how these cellular components are integrated and coordinated needs to be further encouraged. Additionally, there have been great technical advances that have contributed to progress in our understanding of each motility sub-system. For a field currently poised to advance at high speed, it is critical that investigators interact regularly to discuss recent advances vis a vis previous paradigms and future developments. Thus, we have organized a meeting that encourages the cross-fertilization of knowledge from research in each of these areas, with the goal to promote more global thinking about how the mechanical and signaling systems of cell motility are integrated and coordinated. The meeting will include talks on molecular mechanisms, biophysics, and signal transduction, as well as highlights of newly developed technologies that have moved the area along significantly in recent years. The presentations will be delivered by a mixture of invited speakers and speakers selected from submitted abstracts. The latter will be primarily young investigators, while the former will be visionaries giving presentations balanced between new results and general perspectives. Posters sessions will foster one-to-one interactions. Understanding directed cell motility from an integrated perspective is of profound and fundamental importance to many physiological functions and pathological states. A more thorough understanding of the processes involved will impact on multiple health-related issues, such as cancer treatment, wound recovery, and anti-inflammatory therapy.