FASEB Conference: Mamalian Mobile Elements

描述（由申请人提供）：我们请求对将于2005年6月4日至9日在亚利桑那州图森市举行的美国实验生物学学会联合会（FASEB）关于哺乳动物基因组中移动的元素会议提供部分支持。本次会议将突出哺乳动物移动的元素生物学令人兴奋的最新进展，并将提供一个必要的论坛，关键的讨论如何移动的元素已经影响，并继续影响，哺乳动物基因组的进化。会议将围绕四个主题进行。第一个主题将侧重于对哺乳动物移动的元素以及来自其他实验模型系统的相关元素进行的分子生物学和生物化学研究。最近在这些领域的工作引起了极大的兴奋，但也表明需要采取多方面的办法来解决这一领域新出现的问题。第二个主题将侧重于哺乳动物移动的元素的种群遗传和进化分析。受邀演讲者将讨论移动的元素如何影响（并继续影响）哺乳动物基因组，如何在现代哺乳动物基因组中找到“活跃”的移动的元素，以及移动的元素的差异活动如何影响基因表达和人类变异。第三个主要主题将侧重于使用生物信息学方法来确定全基因组序列中新的移动的元件类别。鉴于已经完成或将在未来几年完成的基因组序列过多，这个主题非常及时。会议的最后一个主题将集中在转座子工程。受邀的讲者将讨论DNA转座子和反转录转座子在小鼠诱变研究中的应用，以及移动的元件作为基因传递剂的应用。因此，本次会议将使这些相互关联的领域的研究人员分享有关哺乳动物移动的元素领域令人兴奋的新发现，实验挑战和悬而未决的问题的信息。

DESCRIPTION (provided by applicant): We request partial support for the Federation of American Societies of Experimental Biology (FASEB) conference on Mobile Elements in the Mammalian Genome, to be held from June 4-9, 2005 in Tucson, Arizona. This meeting will highlight exciting recent advances in mammalian mobile element biology, and will provide a needed forum for critical discussions about how mobile elements have impacted, and continue to influence, the evolution of mammalian genomes. The meeting will be organized around four major themes. The first theme will focus on molecular biological and biochemical studies conducted on mammalian mobile elements as well as related elements from other experimental model systems. Recent work in these areas has fostered a great deal of excitement, but also has indicated a need for multifaceted approaches to tackle emerging questions in the field. The second theme will focus on population genetic and evolutionary analysis of mammalian mobile elements. The invited speakers will discuss how mobile elements have impacted (and continue to impact) mammalian genomes, how to find 'active' mobile elements in modern mammalian genomes, and how differential activity of mobile elements influences gene expression and human variation. The third major theme will focus on the use of bioinformatic methodologies to identify new classes of mobile elements in whole genome sequences. This theme is very timely given the plethora of genome sequences that either are completed or will be completed in the coming years. The last theme of the meeting will focus on transposon engineering. The invited speakers will discuss the use of both DNA transposons and retrotransposons in mouse mutagenesis studies and the use of mobile elements as gene delivery agents. Thus, this conference will allow investigators in these interrelated fields to share information about exciting new findings, experimental challenges, and outstanding questions in the area of mammalian mobile elements.