Gordon Res. Conf: Signal Transduction Within The Nucleus

戈登水库。

• 批准号: 6939703
• 负责人: Daniel M. Raben
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-01 至 2006-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6939703
• 关键词: biological signal transduction; cell nucleus; meeting /conference /symposium; travel

DESCRIPTION (provided by applicant): This application seeks partial funding for a new Gordon Research conference on Signal Transduction within the Nucleus to be held February 6-11, 2005 at the Rancho Santa Barbara Marriott, Buellton, California. The funds requested will be used exclusively to support the conference and travel expenses of junior investigators who will be attending the conference and presenting their work as invited presentations, short talks or posters. The broad goal of this conference is to provide a form for review and discussion of recent research on the emerging field of nuclear signaling. This field centers on the novel concept that, similar to the agonist-induced metabolism at the plasma membrane, agonist stimulation leads to the generation of second messengers at and within the nucleus that leads to the production of nuclear localized second messengers. The mechanisms involved in regulating the generation and metabolism of these second messengers, and their precise physiological roles, are part of a complex picture that involves many enzymes and regulatory molecules. This conference brings together a wide variety of investigators focused on understanding the agonist-induced modulation of these components. Some of the principal enzymes include phosphoinositide-specific phospholipase Cs, phosphatidylinositol 3-kinases, phosphatidylcholine-specific phospholipase Cs, phospholipase A2s, lipoxygenases, cyclooxygenases, sphingomyelinases and glycosylating enzymes. These enzymes modulate the levels of key signaling molecules such as diacylglycerol, inositol phosphates, D-3 phosphonylated phosphoinositides, arachidonic acid and related eicosanoid, glycoproteins, glycolipids and sphingolipids. To address important physiological roles, other topics will include nuclear events that are regulated by the nuclear signaling pathways such as chromatin remodeling, transcription and RNA transport. Additional topics focus on how these pathways contribute to disease processes. The requested funds will be invaluable to the support of this conference.

描述（由申请人提供）：本申请为2005年2月6日至11日在加利福尼亚州布尔顿市的Rancho Santa Barbara Marriott举行的核心转导信号转导的新戈登研究会议寻求部分资金。要求的资金将专门用于支持初级调查人员的会议和旅行费用，他们将参加会议并作为邀请演讲，简短的谈判或海报展示其工作。这次会议的广泛目标是为审查和讨论有关核信号新兴领域的最新研究的形式。该田间以新颖的概念为中心，该概念类似于激动剂诱导的质膜代谢，激动剂刺激导致在细胞核中和内部产生核局部第二个使者的核内和内部的第二使者。调节这些第二使者的产生和代谢及其精确生理作用的机制是涉及许多酶和调节分子的复杂图片的一部分。这次会议汇集了各种各样的研究人员，专注于了解激动剂引起的这些组件的调节。一些主要酶包括磷酸肌醇特异性磷脂酶CS，磷脂酰肌醇3-激酶，磷脂酰胆碱特异性磷脂酶CS，磷脂酶A2S，Lipoxygasyse酶，Lipoxygenase酶，环氧酶，鞘磷脂，鞘磷脂酶，甲状腺素甲酶糖苷。这些酶调节关键信号分子的水平，例如二酰基甘油，肌醇磷酸盐，D-3磷酸化磷酸辛糖苷，花生四烯酸和相关的eicosanoid，糖蛋白，糖蛋白，糖脂糖蛋白，糖脂脂和鞘脂。为了解决重要的生理作用，其他主题将包括受核信号通路（例如染色质重塑，转录和RNA转运）调节的核事件。其他主题着重于这些途径如何促进疾病过程。要求的资金对于本次会议的支持将是无价的。