Gordon Res. Conf: Signal Transduction Within The Nucleus

描述(由申请者提供)：本申请旨在为将于2005年2月6日至11日在加利福尼亚州布尔顿市的兰乔圣巴巴拉万豪酒店举行的关于核内信号转导的戈登研究会议寻求部分资金。请拨的资金将专门用于支持初级调查员的会议和旅费，这些调查员将出席会议并以应邀发言、简短演讲或海报的形式介绍他们的工作。这次会议的广泛目标是提供一种形式，供审查和讨论关于新兴核信号领域的最新研究。这一领域集中在一个新的概念上，即类似于激动剂诱导的质膜新陈代谢，激动剂刺激导致在核和核内产生第二信使，从而导致核局部第二信使的产生。调控这些第二信使的产生和代谢的机制，以及它们确切的生理作用，是涉及许多酶和调节分子的复杂图景的一部分。这次会议汇集了各种各样的研究人员，他们专注于了解激动剂诱导的这些成分的调节。一些主要的酶包括磷脂酰肌醇特异性磷脂酶Cs、磷脂酰肌醇3-激酶、磷脂酰胆碱特异性磷脂酶Cs、磷脂酶A2、脂氧合酶、环氧合酶、神经鞘磷脂酶和糖基化酶。这些酶调节关键信号分子的水平，如二酰甘油、肌醇磷酸盐、D-3磷酸化的磷脂酰肌醇、花生四烯酸和相关的二十烷类化合物、糖蛋白、糖脂和鞘磷脂。为了解决重要的生理作用，其他主题将包括由核信号通路调节的核事件，如染色质重塑、转录和RNA运输。其他主题侧重于这些途径如何促进疾病过程。所要求的资金对本次会议的支助将是无价的。

DESCRIPTION (provided by applicant): This application seeks partial funding for a new Gordon Research conference on Signal Transduction within the Nucleus to be held February 6-11, 2005 at the Rancho Santa Barbara Marriott, Buellton, California. The funds requested will be used exclusively to support the conference and travel expenses of junior investigators who will be attending the conference and presenting their work as invited presentations, short talks or posters. The broad goal of this conference is to provide a form for review and discussion of recent research on the emerging field of nuclear signaling. This field centers on the novel concept that, similar to the agonist-induced metabolism at the plasma membrane, agonist stimulation leads to the generation of second messengers at and within the nucleus that leads to the production of nuclear localized second messengers. The mechanisms involved in regulating the generation and metabolism of these second messengers, and their precise physiological roles, are part of a complex picture that involves many enzymes and regulatory molecules. This conference brings together a wide variety of investigators focused on understanding the agonist-induced modulation of these components. Some of the principal enzymes include phosphoinositide-specific phospholipase Cs, phosphatidylinositol 3-kinases, phosphatidylcholine-specific phospholipase Cs, phospholipase A2s, lipoxygenases, cyclooxygenases, sphingomyelinases and glycosylating enzymes. These enzymes modulate the levels of key signaling molecules such as diacylglycerol, inositol phosphates, D-3 phosphonylated phosphoinositides, arachidonic acid and related eicosanoid, glycoproteins, glycolipids and sphingolipids. To address important physiological roles, other topics will include nuclear events that are regulated by the nuclear signaling pathways such as chromatin remodeling, transcription and RNA transport. Additional topics focus on how these pathways contribute to disease processes. The requested funds will be invaluable to the support of this conference.