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Development of pH-sensitive size reducible nanoparticles for cell nucleus target delivery in multidrug-resistant breast cancer

Development of pH-sensitive size reducible nanoparticles for cell nucleus target delivery in multidrug-resistant breast cancer
开发用于多重耐药乳腺癌细胞核靶向递送的 pH 敏感尺寸可缩减纳米颗粒
批准号:
22K12822
负责人:
Lee Ruda
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2022
资助国家:
日本
项目状态:
未结题
起止时间:
2022-04-01 至 2025-03-31

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中文摘要
翻译
于二零二二财政年度,我计划开发及优化聚合物特性。我用EGF受体靶向肽修饰D-α-生育酚聚乙二醇1000琥珀酸酯(TPGS)并评价其偶联性。我成功地制备了TPGS-EGF聚合物并配制了载药胶束。为了将胶束直接递送到细胞核中,我们使用150 nm大小的脂质体将胶束封端。结果,约10个胶束被捕获在脂质体中,并且载药效率增加至胶束的4倍。脂质体包括pH敏感部分,并且释放曲线开始得到证实。
英文摘要
In FY2022, I planned to develop and optimize the polymer characteristic. I modified D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) with EGF receptor-targeted peptide and evaluated the conjugation. I successfully prepared the TPGS-EGF polymer and formulated drug-loaded micelles. We confirm the micelles' characteristics are suitable to move next step.To deliver the micelles directly into the nucleus, we capped the micelles using a 150 nm size liposome. As a result, about ten micelles are captured in the liposome, and the drug loading efficacy was increased up to 4 times that of the micelles. The liposome included pH-sensitive moieties, and the release profile started to confirm.
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Korea Basic Science Institute, Seoul/Kangwon National University/Chonnam National University(韓国)
韩国基础科学研究所,首尔/国立江原大学/国立全南大学(韩国)
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通讯作者:
Overcoming multi drug resistance in 3D breast cancer cell model by pH-sensitive biomimetic nanoparticles
  • 批准号:
    20K20203
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
  • 资助金额:
    $2.66万
  • 财政年份:
    2020
  • 负责人:
    Lee Ruda
  • 依托单位:
海外基金