Conference on Molecular Regulation of Stem Cells

描述（由申请人提供）：由于干细胞的使用承诺了无数的治疗可能性，干细胞继续具有巨大的科学和临床兴趣。对新干细胞群体的鉴定所产生的最初的兴奋已经让位于对操纵其分化和自我更新能力的方法的更集中的努力。许多基因组规模的研究正在进行中，以编目干细胞基因表达谱或在干细胞控制基因中产生小鼠突变体。再加上更经典的单基因或通路方法来研究干细胞生物学，到2005年，干细胞功能的一些细节应该开始被揭示出来。这样的基本认识将为临床的快速发展提供基础。本次会议将汇集顶尖的干细胞生物学家，特别是在胚胎干细胞、神经干细胞和造血干细胞领域，讨论干细胞功能的分子机制。

DESCRIPTION (provided by the applicant): Stem cells continue to be of enormous scientific and clinical interest, due to the myriad therapeutic possibilities promised by their use. The initial excitement generated by identification of novel stem cell populations has given way to more focused effort on methods to manipulate their differentiation and self-renewal capacities. A number of genome-scale studies are now underway to catalog stem cell gene expression profiles or generate mouse mutants in stem cell-control genes. Coupled with more classical single gene or pathway approaches to stem cell biology, by 2005, some of the nuts-and-bolts of stem cell function should begin to be revealed. Such fundamental understanding will provide the foundation for more rapid advances toward the clinic. This conference will bring together top stem cell biologists, particularly in the areas of embryonic, neural, and hematopoietic stem cells, to discuss molecular mechanisms of stem cell function.