5th International Symposium on Hormonal Carcinogenesis

描述(申请人提供)：第五届荷尔蒙癌症发生国际研讨会(ISHC)的主要目标是聚集不同的研究人员、流行病学家、基础科学家和临床医生，讨论类固醇和多肽激素以及生长因子在一些在美国和世界范围内困扰女性和男性的最常见癌症的病因、依赖性和最终的激素抵抗中所起的作用。这次ISHC将强调癌症研究中的前沿进展，将类固醇激素与以下几个方面联系起来：1)干细胞研究，2)有丝分裂酶的过度表达，3)类固醇激素受体在激素依赖型肿瘤向非激素依赖型肿瘤演变中的意义，4)类固醇受体在非激素依赖型组织(如肺和结肠)实体肿瘤中的作用，以及5)根据这些发现开发治疗策略。这次研讨会的计划安排是很平衡的。它包括基础科学家主要感兴趣的会议，强调导致肿瘤发生、激素依赖和独立性的分子事件，以及具有良好翻译(临床前)成分的医生具有强烈临床相关性的其他会议。发言的主要群体包括妇女和代表性不足的少数族裔。第五届ISHC科学计划被分成四个领域，与荷尔蒙致癌和荷尔蒙癌症相关的具体问题有关。区域1：与荷尔蒙癌症有关的病因学。A)成人乳腺癌和前列腺癌干细胞的细胞起源，第1节和第1次最新技术报告。B)乳腺、前列腺癌、血液病的有丝分裂酶、中心体扩增和基因组不稳定，第2节和第3节最新技术报告。C)类固醇受体相互作用，第三节。区域2：与激素相关的癌症危险因素。d)。乳房、卵巢、前列腺、结直肠、肺的风险评估、生物标记物和激素受体，第4、7和第二届最新技术报告。领域3：预防和治疗。E)关于乳腺癌、前列腺癌和卵巢癌，第5次会议和第二次最新技术报告。领域4：激素依赖和独立性。E)前列腺癌、乳腺癌和子宫癌，第6期。与以往一样，将出版一本介绍报告的书。

DESCRIPTION (provided by applicant): The primary goal of the 5th International Symposium on Hormonal Carcinogenesis (ISHC) is to gather a diverse group of research investigators, epidemiologists, basic scientists and clinicians to address the role of steroid and peptide hormones and growth factors in the causation, dependence, and eventual hormonal resistance of some of the most prevalent cancers afflicting women and men in the USA and world-wide. This ISHC will emphasize cutting edge progress in cancer research linking steroid hormones to: 1) Stem cell research, 2) Over-expression of mitotic kinases, 3) Significance of steroid hormone receptors in the evolution of hormone-dependent to -independent tumors, 4) Role of steroid receptors in solid tumors from non-hormone dependent tissues such as lung and colon, and 5) Development of therapeutic strategies derived from these discoveries. The planned program for this Symposium is well balanced. It includes sessions of primary interest to basic scientists that emphasize the molecular events leading to oncogenesis, hormone dependency and independency, and others of strong clinical relevance to physicians with a sound translational (pre-clinical) component. The prominent group of speakers includes women and under-represented minorities. The 5th ISHC scientific program has been divided into four areas linked to specific issues pertinent to hormonal carcinogenesis and hormonal cancers. Area 1: ETIOLOGY IN RELATION TO HORMONAL CANCERS. a) Cellular origin in adult breast and prostate cancer stem cells, Session 1 and 1st State of the Art presentation. b) Mitotic kinases, amplified centrosomes, and genomic instability in breast, prostate, hematologic malignancies, Session 2 and 3rd State of the Art presentation. c) Steroid receptor interactions, Session 3. Area 2: HORMONE-RELATED CANCER RISK FACTORS. d). Risk assessment, biomarkers, and hormone receptors in breast, ovary, prostate, colorectal, lung, Sessions 4, 7, and 2nd State of the Art presentation. Area 3: PREVENTION AND TREATMENT. e) In relation to breast, prostate, and ovarian cancer, Session 5 and 2nd State of the Art presentation. Area 4: Hormone Dependency and Independency. e) In prostate, breast and uterine cancer, Session 6. As in the past, a book will be published of the presentations.