VII International Skin Carcinogenesis Conference (ISCC)

描述（由申请人提供）：分子生物学的最新技术进步，包括转基因和基因敲除技术的发展，使人们对皮肤肿瘤发展过程中发生的遗传和表观遗传变化的本质有了更多的了解。这些进展极大地改善和扩展了我们对正常细胞向恶性肿瘤发展的机制的概念。目前正在阐明内在遗传因素和外部修饰因素的作用。这导致确定了几个预防和治疗的目标，尽管还需要取得更多的进展。第七届国际皮肤癌会议的目标是提供一个论坛，交流有关非黑色素瘤和黑色素瘤皮肤肿瘤发展过程中发生的生物、细胞和分子变化的最新相关信息。平台和海报会议将重点关注1)皮肤癌的化学预防（临床前和临床研究），2)皮肤癌的转录因子发病机制，3)皮肤癌的遗传模型，4)恶性黑色素瘤的研究模型，5)肿瘤的促进和进展机制，6)肿瘤与基质的相互作用，7)修饰基因和遗传易感性，8)干细胞在皮肤癌中的作用。一半的演讲者将由方案规划委员会邀请，其余的由委员会从提交的摘要中选出。选择标准将包括与本次会议主题的相关性以及研究的创新性或新颖性。将努力实现高级和青年调查人员以及妇女和少数民族的平衡。本次会议旨在汇集来自美国、欧洲和日本主要实验室的大约80-90名研究人员，他们积极从事皮肤癌发展和预防机制的前沿研究。会议将于2006年11月9日至12日在德克萨斯州奥斯汀举行。

DESCRIPTION (provided by applicant): Recent technical advances in molecular biology, including the development of transgenic and gene knockout technologies, have led to increased understanding of the nature of the genetic and epigenetic changes that occur in the development of skin tumors. These advances are greatly improving and expanding our concept of the mechanisms by which normal cells progress to malignancy. The roles of both intrinsic genetic factors and external modifiers are now being elucidated. This is has led to the identification of several targets for prevention and for therapy, although considerably more advances are needed. The goal of the 7th International Skin Carcinogenesis Conference is to provide a forum for exchange of the most recent and relevant information on the biological, cellular and molecular changes that occur during non-melanoma and melanoma skin tumor development. Platform and poster sessions will focus on 1) Chemoprevention of skin cancer (both preclinical and clinical studies), 2) Transcription factor pathogenesis of skin cancer, 3) Genetic models of skin cancer, 4) Models for the study of malignant melanoma, 5) Mechanisms of tumor promotion and progression, 6) Tumor-stroma interactions, 7) Modifier genes and genetic susceptibility, 8) The role of stem cells in skin cancer. Half of the speakers will be invited by the Program Planning Committee, with the remainder being selected by the Committee from submitted abstracts. The criteria for selection will include relatedness to the theme of this conference and the innovativeness or novelty of the research. Efforts will be made to achieve a balance of senior and young investigators, and women and minorities. This meeting is intended to bring together approximately 80-90 researchers from major laboratories in the United States, Europe and Japan that are actively engaged in cutting-edge research on the mechanisms of skin cancer development and prevention. The meeting will be held November 9-12, 2006 in Austin, TX.