6th International Skin Carcinogenesis Conference

第六届国际皮肤癌发生会议

• 批准号: 6879835
• 负责人: SUSAN M FISCHER
• 金额: $ 0.6万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6879835
• 关键词: cancer prevention; carcinogenesis; meeting /conference /symposium; neoplasm /cancer genetics; neoplasm /cancer therapy; neoplastic process; skin neoplasms; travel

DESCRIPTION (provided by applicant): Recent technical advances in molecular biology, including the development of transgenic and gene knockout technologies, have led to increased understanding of the nature of the genetic and epigenetic changes that occur in the development of skin tumors. These advances are greatly improving and expanding our concept of the mechanisms by which normal cells progress to malignancy. The role of both intrinsic genetic factors and external modifiers are now being elucidated. This has led to the identification of several targets for prevention and for therapy, although considerably more advances are needed. The goal of the 6th International Skin Carcinogenesis Conference is to provide a forum for exchange of the most recent and relevant information on the biological, cellular and molecular changes that occur during nonmelanoma and melanoma skin tumor development. Sessions will focus on understanding the genetic factors that can influence skin cancer susceptibility, how alterations in normal cell signaling and proliferation affect the expression of particular genetic alterations, and how intrinsic and extrinsic factors can modify the neoplastic process. This ongoing biannual skin carcinogenesis conference is important for two reasons. The mouse skin paradigm for multistage carcinogenesis has served as a model of discovery where the genetic and epigenetic alterations are applicable to many if not all human epithelial cancers. This is a very highly interactive meeting where it is anticipated that new concepts and ideas will be generated and shared that will have an impact on the prevention and intervention in skin cancer development. Because there is a world-wide increase in the incidence of both melanoma and nonmelanoma skin cancers, new approaches to skin cancer prevention and treatment are needed. This meeting is intended to bring together approximately 80- 100 researchers from major laboratories in the United States, Europe and Japan that are actively engaged in cutting-edge research on the mechanisms of skin cancer development and prevention. The meeting will be held jointly with the Montagna Symposium on the Biology of Skin.

描述（由申请人提供）：分子生物学的最新技术进步，包括转基因和基因敲除技术的发展，导致人们对皮肤肿瘤发展中遗传和表观遗传变化的性质的了解增加了。 这些进步极大地改善和扩展了我们对正常细胞发展为恶性肿瘤的机制的概念。 内在遗传因素和外部修饰符的作用现在正在阐明。 这导致了对预防和治疗的几个靶标确定，尽管需要更多的进步。 第六届国际皮肤致癌会议的目标是提供一个论坛，以交换有关非黑色素瘤和黑色素瘤皮肤肿瘤发育过程中生物学，细胞和分子变化的最新和相关信息。 会议将集中在理解会影响皮肤癌敏感性的遗传因素上，正常细胞信号传导和增殖的变化如何影响特定遗传改变的表达，以及内在和外在因素如何改变肿瘤过程。 这次持续的双年度皮肤致癌会议很重要，原因有两个。 用于多阶段癌变的小鼠皮肤范例已成为一种发现模型，在该模型中，遗传和表观遗传学改变适用于许多（如果不是全部人类上皮癌）。 这是一次非常高度互动的会议，预计将产生和共享新的概念和想法，这将对皮肤癌发展的预防和干预产生影响。 由于黑色素瘤和非黑色素瘤皮肤癌的发生率在全球范围内增加，因此需要用于预防皮肤癌和治疗的新方法。 这次会议旨在将来自美国，欧洲和日本主要实验室的大约80-100名研究人员聚集在一起，他们积极从事有关皮肤癌发育和预防机制的尖端研究。 该会议将与蒙塔格纳（Montagna）关于皮肤生物学的座谈会共同举行。