Oral-Based Diagnostics

描述（由申请人提供）：纽约科学院正计划于2006年10月10日至13日在亚特兰大郊外佐治亚州拉尼尔湖的翡翠角度假村举行一次题为“基于口腔的诊断”的重大科学会议。会议由丹尼尔马拉默德博士组织，纽约大学牙科学院基础科学教授和R。Sam Niedbala博士，利哈伊大学化学教授。口服诊断有可能检测全身性疾病和暴露于各种有害物质的证据，并提供健康和疾病状况的生物标志物。整合新的方法，以口腔为基础的诊断正在扩大，包括基因组学，蛋白质组学，生物信息学和纳米技术。诊断技术的改进正在产生更“方便用户”的方法。最近，在口腔诊断领域中，将实验室测定转化为商业产品的努力有所增加，这可以通过市场上出现的几种新的基于口腔的诊断产品来证明。在这个竞技场中，学术界、政府和工业界的合作关系也正在形成，所有这些无疑都将有助于迅速推进这一领域。本次研讨会的目的之一是汇集毒理学、病理学、口腔生物学、牙科研究和临床医学领域的领导者，讨论口腔诊断领域的进展，并允许发起新的合作。这次会议的成果之一将是汇编这一领域的出版物目录;第二个成果是《纽约科学院年鉴》，其中记录了会议的议事录。除了口腔和全身疾病的诊断，唾液和其他口腔液体的分析允许非侵入性检测暴露于环境毒素，生物恐怖主义和化学战剂，以及滥用物质。此外，口腔流体提供疾病状态的生物标志物，包括心血管疾病、内分泌失调、自身免疫性疾病、癌症和许多传染病的生物标志物。本次会议将重点讨论口腔诊断领域的进展和新技术及其在健康状况检测中的应用。

DESCRIPTION (provided by applicant): The New York Academy of Sciences is planning a major scientific conference entitled, "Oral- Based Diagnostics," to be held from October 10-13, 2006 at the Emerald Pointe Resort on Lake Lanier, GA, outside Atlanta. The conference is being organized by Daniel Malamud, Ph.D., Professor of Basic Sciences, New York University College of Dentistry and R. Sam Niedbala, Ph.D., Professor of Chemistry, Lehigh University. Oral-based diagnostics have the potential to detect systemic disease and evidence of exposure to various harmful substances, as well as provide biomarkers of health and disease status. Integration of novel approaches to oral based diagnostics is expanding to include genomics, proteomics, bioinformatics and nanotechnology. Improved technologies for diagnostics are resulting in more "user-friendly" methods. Efforts to translate bench assays to commercial products in the area of oral diagnostics have increased recently as witnessed by the appearance of several new oral based diagnostic products in the market place. Collaborative academic, government and industry relationships in this arena are also forming all of which will undoubtedly serve to rapidly advance the field. One of the aims of this symposium is to bring together leaders in the areas of toxicology, pathology, oral biology, dental research, and clinical medicine to discuss advances in the field of oral diagnostics, and to permit the initiation of new collaborations. One outcome of this conference will be the compilation of a bibliography of publications in this area; a second will be the volume of the Annals of the NY Academy of Sciences, documenting the proceedings of the conference. In addition to diagnosis of oral and systemic diseases, analysis of saliva and other oral fluids permits non-invasive detection of exposure to environmental toxins, agents of bioterrorism and chemical warfare, as well as substances of abuse. Moreover, oral fluids provide biomarkers of disease status including those for cardiovascular disease, endocrine disorders, autoimmune diseases, cancer, and many infectious diseases. This conference will focus on advances and new technologies in the oral diagnostics field and their utility for detection of health status.