Design and Synthesis of New Molecular Scaffolds for Medicinal Chemistry

药物化学新型分子支架的设计与合成

• 批准号: 2619284
• 金额: --
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2619284
• 关键词: Design; Synthesis; New; Molecular; Scaffolds

The project will focus on the design and synthesis of new scaffolds that mimic privileged architectures in medicinal chemistry. The work will involve a combination of computational design linked to the development of new synthetic methods to synthesise and elaborate the scaffolds. The approach will be validated by selecting existing drug molecules and making these mimics, testing their physical and biological properties against the parent system.

该项目将专注于设计和合成新的支架，模仿药物化学中的特殊结构。这项工作将涉及将计算设计与开发新的合成方法相结合，以合成和精心制作支架。该方法将通过选择现有的药物分子和制造这些模拟物来验证，测试它们与母体系统的物理和生物特性。