Regulation of Eukaryotic Transcription:Chromatin to mRNA

真核转录的调控：染色质到 mRNA

• 批准号: 7058654
• 负责人: James Goodrich
• 金额: $ 0.5万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-14 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7058654
• 关键词: chromatin; genetic regulation; genetic transcription; meeting /conference /symposium; messenger RNA; neoplasm /cancer genetics; travel

DESCRIPTION (provided by applicant): This meeting will encompass the most exciting current research on eukaryotic mRNA transcription and its regulation. Sessions will address the following pivotal topics in the field: how chromatin and its modification actively sets levels of gene-specific transcription; promoter recognition complexes and their function in directing transcription initiation; the structure and organization of large macromolecular transcription complexes as revealed by X-ray crystallography and electron microscopy; transcriptional coregulatory complexes and their roles as mediators of transcriptional regulation during differentiation and development; the steps in the transcript synthesis reaction; and the application of emerging imaging techniques to the real time analysis of transcription in living cells. The goals of this meeting are to report the most recent progress on these topics, as well as to provide an understanding of both detailed transcriptional regulatory mechanisms and how transcriptional regulation integrates with other cellular and developmental processes. The meeting will focus on recent advances in the study of eukaryotic transcription, which is the process of copying DNA into RNA during the first step of gene expression. Transcription and its regulation in a gene specific fashion are central to all of biology. Many genetic diseases and cancers result from aberrant transcriptional regulation.

描述（由申请人提供）：本次会议将包括最令人兴奋的真核mRNA转录及其调控的研究。会议将解决该领域的以下关键主题：染色质及其修饰如何积极设置基因特异性转录水平;启动子识别复合物及其在指导转录起始中的功能;通过X射线晶体学和电子显微镜揭示的大分子转录复合物的结构和组织;转录共调节复合物及其在分化和发育过程中作为转录调节介质的作用;转录合成反应的步骤;以及新兴成像技术在活细胞转录的真实的时间分析中的应用。 本次会议的目标是报告这些主题的最新进展，以及提供详细的转录调控机制和转录调控如何与其他细胞和发育过程相结合的理解。会议将重点讨论真核转录研究的最新进展，真核转录是基因表达的第一步，将DNA复制成RNA的过程。转录及其在基因特异性方式的调节是所有生物学的核心。许多遗传性疾病和癌症是由异常的转录调控引起的。