2006 Grover Conference on the Pulmonary Circulation - Rho Family GTPases

描述（由申请人提供）： 此申请要求资金支持2006年肺循环格雷弗会议 题为“Rho Family GTPases in Pulmonary Vascular Pathophysiology.“本次会议旨在将最先进的实验室研究与临床问题相结合，这些问题是肺部疾病发病率和死亡率的主要原因。Rho家族GTP酶（例如RhoA、Cdc42和Rac1）在肺生物学和病理学中的重要作用正在迅速显现。这些信号传导分子与多种细胞功能（收缩、渗透性、炎症、增殖、迁移、基因表达、分化）有关，并正在成为全身和肺血管疾病的治疗靶点。事实上，多效性他汀类药物可能部分通过抑制Rho GTP酶的活化而起作用。 Rho激酶抑制剂可用于治疗脑和冠状动脉血管痉挛的试验。Rho GTP酶在肺循环中发挥的多方面作用正在朝着肺动脉高压、ARDS、肺水肿等的治疗方向发展。然而，还没有一个单一的、全面的会议来促进对Rho GTP酶在肺生物学和病理学中感兴趣的研究者之间的互动和思想交流。具体而言，2006年Grover会议旨在为Rho GTP酶的细胞生物学以及肺和血管生物学的专家提供一个论坛，以严格解决：（1）Rho家族GTP酶的细胞生物学，包括激活，信号传导等，(2)通过Rho家族GT3信号传导调节肺血管张力和活性，即，钙致敏和平滑肌收缩、内皮渗透性，（3）损伤后炎性细胞向肺的募集和活化等，以及（4）Rho家族GTP酶作为医学（例如肺动脉高压、ARDS等）中的治疗靶。2006年格罗弗会议将是该系列的第13届会议，代表了关于肺循环的历史最长的会议。发言和讨论的时间相等，以优化互动。会议将于2006年9月6日至10日在科罗拉多州塞达利亚的失落谷牧场举行。牧场是一个亲密的环境，鼓励科学家和临床医生之间的互动。我们正在申请资金，以支持受邀演讲者的差旅和住宿。

DESCRIPTION (provided by applicant): This application requests funding to support the 2006 Graver Conference on the Pulmonary Circulation entitled "Rho Family GTPases in Pulmonary Vascular Pathophysiology." This conference seeks to integrate state of the art bench research with clinical problems that are leading causes of morbidity and mortality from lung disease. The important roles Rho family GTPases (e.g. RhoA, Cdc42, and Rac1) play in lung biology and pathology are rapidly emerging. These signaling molecules have been implicated in a wide variety of cellular functions (contraction, permeability, inflammation, proliferation, migration, gene expression, differentiation) and are emerging as therapeutic targets in systemic and pulmonary vascular diseases. Indeed, the pleiotropic statins may act in part by inhibiting the activation of Rho GTPases. Inhibitors of Rho-kinase are available for in trials for treatment of cerebral and coronary artery vasospasm. The multifaceted role that Rho GTPases play in the pulmonary circulation is evolving toward treatments for pulmonary hypertension, ARDS, pulmonary edema, etc. However, there has not yet been a single, comprehensive conference to promote interaction and exchange of ideas amongst investigators interested in Rho GTPases in lung biology and pathology. Specifically, the 2006 Grover Conference seeks to provide a forum for experts in the cellular biology of Rho GTPases and in lung and vascular biology to rigorously address the: (1) Cell biology of Rho family GTPases including activation, signaling, etc., (2) Regulation of pulmonary vascular tone and activity through Rho family GTPase signaling, i.e., calcium sensitization and smooth muscle contraction, endothelial permeability, (3) Recruitment and activation of inflammatory cells to the lung following injury, etc., and (4) Rho family GTPases as therapeutic targets in medicine (e.g. pulmonary hypertension, ARDS, etc.). The 2006 Grover Conference will be the 13th in this series, representing the longest-standing conference on the pulmonary circulation. Equal time is given to presentation and discussion to optimize interaction. The conference will be held at the Lost Valley Ranch in Sedalia, CO September 6-10, 2006. The ranch is an intimate setting that encourages interaction between scientists and clinicians. We are requesting funding to support travel and lodging for invited speakers.