2006 Grover Conference on the Pulmonary Circulation - Rho Family GTPases

描述(由申请人提供)： 本申请申请资助2006年格雷弗肺循环会议 题为“肺血管病理生理学中的Rho家族GTP酶”。本次会议寻求将最先进的工作台研究与临床问题相结合，这些问题是肺部疾病发病率和死亡率的主要原因。Rho家族GTP酶(如RhoA、CDC42和rac1)在肺部生物学和病理学中的重要作用正在迅速显现。这些信号分子参与多种细胞功能(收缩、通透性、炎症、增殖、迁移、基因表达、分化)，并正在成为全身和肺血管疾病的治疗靶点。事实上，多效性的他汀类药物可能部分通过抑制Rho GTP酶的激活而起作用。Rho-Kinase的抑制剂可用于治疗大脑和冠状动脉血管痉挛的试验。Rho GTP酶在肺循环中发挥的多方面作用正在向治疗肺动脉高压、ARDS、肺水肿等方向发展。然而，目前还没有一个单一的、全面的会议来促进对Rho GTP酶在肺部生物学和病理学中的兴趣的研究人员之间的互动和思想交流。具体地说，2006年Grover大会旨在为Rho家族GTP酶的细胞生物学以及肺和血管生物学的专家提供一个论坛，以严格讨论：(1)Rho家族GTP酶的细胞生物学，包括激活、信号等；(2)通过Rho家族GTP酶信号调节肺血管张力和活动，即钙敏化和平滑肌收缩，内皮通透性，(3)损伤后炎症细胞的招募和激活等，以及(4)Rho家族GTP酶作为医学治疗靶点(如肺动脉高压、ARDS等)。2006年格罗弗会议将是该系列的第13次会议，是历史最长的肺循环会议。演讲和讨论的时间是相等的，以优化互动。会议将于2006年9月6日至10日在科罗拉多州塞达利亚的Lost Valley牧场举行。牧场是一个鼓励科学家和临床医生互动的亲密环境。我们正在申请资金，以支持受邀演讲者的旅行和住宿。

DESCRIPTION (provided by applicant): This application requests funding to support the 2006 Graver Conference on the Pulmonary Circulation entitled "Rho Family GTPases in Pulmonary Vascular Pathophysiology." This conference seeks to integrate state of the art bench research with clinical problems that are leading causes of morbidity and mortality from lung disease. The important roles Rho family GTPases (e.g. RhoA, Cdc42, and Rac1) play in lung biology and pathology are rapidly emerging. These signaling molecules have been implicated in a wide variety of cellular functions (contraction, permeability, inflammation, proliferation, migration, gene expression, differentiation) and are emerging as therapeutic targets in systemic and pulmonary vascular diseases. Indeed, the pleiotropic statins may act in part by inhibiting the activation of Rho GTPases. Inhibitors of Rho-kinase are available for in trials for treatment of cerebral and coronary artery vasospasm. The multifaceted role that Rho GTPases play in the pulmonary circulation is evolving toward treatments for pulmonary hypertension, ARDS, pulmonary edema, etc. However, there has not yet been a single, comprehensive conference to promote interaction and exchange of ideas amongst investigators interested in Rho GTPases in lung biology and pathology. Specifically, the 2006 Grover Conference seeks to provide a forum for experts in the cellular biology of Rho GTPases and in lung and vascular biology to rigorously address the: (1) Cell biology of Rho family GTPases including activation, signaling, etc., (2) Regulation of pulmonary vascular tone and activity through Rho family GTPase signaling, i.e., calcium sensitization and smooth muscle contraction, endothelial permeability, (3) Recruitment and activation of inflammatory cells to the lung following injury, etc., and (4) Rho family GTPases as therapeutic targets in medicine (e.g. pulmonary hypertension, ARDS, etc.). The 2006 Grover Conference will be the 13th in this series, representing the longest-standing conference on the pulmonary circulation. Equal time is given to presentation and discussion to optimize interaction. The conference will be held at the Lost Valley Ranch in Sedalia, CO September 6-10, 2006. The ranch is an intimate setting that encourages interaction between scientists and clinicians. We are requesting funding to support travel and lodging for invited speakers.