Gordon Conference: Cancer Genetics and Epigenetics 2003

描述(申请人提供)：本申请是为一个名为“癌症遗传学和表观遗传学”的会议提供部分资金，该会议由戈登研究会议(GRC)主办，将于2003年1月中旬在加利福尼亚州文图拉的喜来登港口城举行。这将是全球资源中心关于这一主题的第四次两年一次的会议，在这一领域特别令人兴奋的时刻。本次会议涵盖的所有领域的工作都在以越来越快的速度取得进展。这使得研究人员之间的沟通变得更加重要。在这次会议上，致力于癌症研究的选定方面和相关的基本遗传/表观遗传机制的与会者(最多130人)将就当前主题的演讲进行辩论，批评海报演讲，并开展非正式讨论。会议将包括九个演讲者会议和每日海报会议。海报演示文稿以及九位以上的发言者将从提交的摘要中选出。因此，这次会议将为年轻的研究人员和最新数据提供一个很好的展示窗口，并有国际知名的资深科学家参加。按照这一系列会议的传统，将强调正式讨论，每次演讲后留出15-20分钟用于辩论。这次会议将为致力于癌症分子生物学的研究人员和致力于基因调控基本机制的研究人员之间提供一个交流信息的论坛。根据表观基因调控以及癌症和癌前组织中DNA损伤的分子反应等统一主题，已经准备了一份科学演讲的大纲时间表。这些讲座将涉及肿瘤抑制和癌基因功能的选定方面，DNA甲基化导致的基因沉默，基因组印记和染色质改变，DNA修复和重组。在分子流行病学的背景下，将有一次会议处理这些相同的主题，两次会议将处理乳腺癌和血液病癌症的这些主题。最近的发现继续揭示连接这些领域的机制，因此我们预计调查人员之间的相互作用将产生协同进展。

DESCRIPTION (provided by applicant): This application is for partial funding of a conference called "Cancer Genetics and Epigenetics" to be held under the auspices of the Gordon Research Conference (GRC) in mid-January 2003 at the Sheraton Harbortown, Ventura, California. This will be the fourth biennial GRC conference on this topic during a particularly exciting time for the field. Work in all areas covered by this conference is progressing at an ever-increasing pace. This makes communication between researches ever more essential. At this conference, the attendees (130 maximum) working on selected aspects of cancer research and pertinent basic genetic/epigenetic mechanisms will debate presentations on current topics, critique poster presentations, and develop informal discussions. The meeting will feature nine speaker sessions and daily poster sessions. Poster presentations, as well as more than nine of the speakers, will be chosen from the submitted abstracts. Therefore, this conference will provide a good showcase for younger investigators and late-breaking data, as well as featuring internationally renowned senior scientists. In the tradition of this conference series, there will be emphasis on formal discussion, with 15-20 minutes set aside for debate after each talk. This conference will provide a forum for exchange of information between investigators working on the molecular biology of cancer and those working on basic mechanisms of gene regulation. An outline schedule of scientific talks has been prepared based on the unifying themes of epigenetic gene regulation and the molecular responses to DNA damage in cancers and in cancer precursor tissues. These talks will cover selected aspects of tumor suppressor and oncogene function, gene silencing by DNA methylation, genomic imprinting and chromatin alterations, DNA repair and recombination. There will be one session dealing with these same topics in the setting of molecular epidemiology, and two sessions will deal with these topics in breast cancer and hematological cancers. Recent discoveries continue to uncover mechanisms linking these areas, so we expect that cross talk among investigators will yield synergistic advances.