Workshops on Viral Pathogenesis and Oncogenesis

描述(由申请者提供)：申请资金以继续举办癌症病毒学跨学科方面的年度系列会议。癌症病毒一直是科学研究的重要对象，因为1)它们为基本的癌症过程提供了大量的见解，2)全世界大约20-25%的癌症都有病毒病因。虽然有几个专门的会议处理特定致癌病毒的生物化学和分子生物学，但没有会议以跨学科的方式处理所有这些病毒。这笔赠款支持的会议满足了这一需求。在竞争更新的第一次会议上，我们提出了“病毒致癌基因”的主题。这次会议将汇聚致癌逆转录病毒、疱疹病毒(EBV、KSHV、HVS)、乳头瘤病毒(HPV)、乳头状病毒(SV40、多瘤)和肝炎病毒的研究人员。在过去的几年里，人们已经了解了大量关于病毒癌基因的工作原理，包括激活信号转导通路和灭活肿瘤抑制蛋白。一个跨学科的会议将是有价值的，因为不同的致癌病毒实际上可能在转化中利用相同的途径。此外，很明显，大多数病毒癌基因影响多个细胞途径，以及病毒转化的多因素性质也将被探索。未来几年的会议将讨论诸如癌症中的新型病毒感染、病毒组装、对病毒感染的免疫反应以及病毒的潜伏期和持久性等主题。

DESCRIPTION (provided by applicant): Funds are requested to continue an annual series of meetings on interdisciplinary aspects of cancer virology. Cancer viruses have been important subjects for scientific study, since 1) they have provided numerous insights into basic cancer processes, and 2) ca. 20-25% of cancer worldwide has a viral etiology. While there are several specialty meetings that deal with the biochemistry and molecular biology of particular oncogenic viruses, there are no meetings that deal with all of these viruses in an interdisciplinary fashion. The meetings supported by this grant fill that need. For the first meeting in the competing renewal, we propose the topic of "Viral Oncogenes". This meeting will bring together researchers on oncogenic retroviruses, herpesviruses (EBV, KSHV, HVS), papillomaviruses (HPV), papovaviruses (SV40, polyoma), and hepadnaviruses. Over the past years, a great deal has been learned about how viral oncogenes work, including activation of signal transduction pathways and inactivation of tumor suppressor proteins. An interdisciplinary meeting will be valuable since different oncogenic viruses actually may utilize the same pathways in transformation. Also, it has become clear that most viral oncogenes affect multiple cellular pathways, and the multifactorial nature of viral transformation will be explored as well. Meetings in subsequent years will address topics such as Novel Viral Infections in Cancer, Viral Assembly, Immune Responses to Viral Infections, and Viral Latency and Persistence.