Workshops On Viral Oncogenesis and Pathogenesis

请拨资金继续举行关于癌症病毒学跨学科方面的年度系列会议。癌症病毒一直是科学研究的重要对象，因为1)它们为基本的癌症过程提供了许多见解，2)全世界约20-25%的癌症具有病毒病因。虽然有几个专门的会议处理特定致癌病毒的生物化学和分子生物学，但没有其他会议以跨学科的方式处理所有这些病毒。在竞争更新的第一次会议上，我们提出了“与人类癌症相关的新病毒”的主题。最近发现了新的人类癌症候选病毒，最著名的是默克尔细胞癌中的MCPyV和前列腺癌中的XMRV；其他人类癌症的候选病毒也已被确定。本次会议将使研究这些新病毒的研究人员与研究现有人类致癌病毒的研究人员齐聚一堂，这些病毒包括疱疹病毒（EBV、KSHV）、乳头瘤病毒（HPV）、逆转录病毒（HTLV-I）和肝炎病毒（HBV和HCV）。跨学科会议将是有价值的，因为不同的致瘤病毒在致瘤转化中使用不同的机制（直接和间接），这将为新的候选人类致瘤病毒提供重要的概念框架。随后几年的会议将讨论诸如病毒和细胞内运输、病毒致癌基因、病毒潜伏期和持久性以及病毒表达的转录后调控等主题。

Funds are requested to continue an annual series of meetings on interdisciplinary aspects of cancer virology. Cancer viruses have been important subjects for scientific study, since 1) they have provided numerous insights into basic cancer processes, and 2) ca. 20-25% of cancer worldwide has a viral etiology. While there are several specialty meetings that deal with the biochemistry and molecular biology of particular oncogenic viruses, there are no other meetings that deal with all of these viruses in an interdisciplinary fashion. For the first meeting in the competing renewal, we propose the topic of "New Viruses Associated with Human Cancer". Recently new candidate viruses for human cancers have been identified, most notably MCPyV in Merkel cell carcinoma and XMRV in prostate cancer; additional candidate viruses for other human cancers also have been identified. This meeting will bring together researchers on these new viruses with those working on established human oncogenic viruses including herpesviruses (EBV, KSHV), papillomaviruses (HPV), retroviruses (HTLV-I), and hepatitis viruses (HBV and HCV). An interdisciplinary meeting will be valuable since different oncogenic viruses use different mechanisms in oncogenic transformation (direct and indirect), which will provide important conceptual frameworks for the new candidate human oncogenic viruses. Meetings in subsequent years will address topics such as Viruses and Intracellular Trafficking, Viral Oncogenes, Viral Latency and Persistence, and Post-transcriptional Regulation of Viral Expression.