COBALT COMPLEXES OF MODIFIED NUCLEOSIDES, DINUCLEOSIDES

修饰核苷、二核苷的钴络合物

• 批准号: 6848642
• 负责人: ROMAN DEMBINSKI
• 金额: $ 21.68万
• 依托单位: OAKLAND UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6848642
• 关键词: MCF7 cell; antineoplastics; bicyclic compound; breast neoplasms; cell line; chemical structure function; cobalt; cyclic compound; drug design /synthesis /production; drug screening /evaluation; human genetic material tag; ligands; neoplasm /cancer chemotherapy; neoplasm /cancer pharmacology; nucleoside analog; nucleosides; organometallic compounds

DESCRIPTION (provided by applicant): Although cytotoxic nucleoside analogues and transition metals were among the first chemotherapeutic agents to be introduced for the medical treatment of cancer, the availability of a combination of both classes of compounds remains scarce, mostly due to synthetic challenges. We propose here a new synthetic methodology for the synthesis of bicyclic modified nucleosides that can be converted into their organometallics. Pursuing the leading structures of hexacarbonyl dicobalt complexes that exhibit activity against human mammary tumor cells, we will synthesize a library of new metallonucleosides and conduct structure-activity relationship studies.

描述（由申请人提供）：尽管细胞毒性核苷类似物和过渡金属是最早用于癌症医疗治疗的化学治疗剂之一，但两类化合物的组合仍然很少，主要是由于合成挑战所致。我们在这里提出了一种新的合成方法，用于合成双环修饰的核苷，可以转化为有机金属。追求对人类乳腺肿瘤细胞表现活性的己钙龙二核核酸甲状腺菌复合物的主要结构，我们将合成一个新的金属核苷的库并进行结构活性关系研究。

项目成果

Organometallic Nucleosides: Synthesis and Biological Evaluation of Substituted Dicobalt Hexacarbonyl 2'-Deoxy-5-oxopropynyluridines.

• DOI: 10.1002/open.201700168
• 发表时间: 2018-03
• 期刊: ChemistryOpen
• 影响因子: 2.3
• 作者: Kaczmarek R;Korczyński D;Królewska-Golińska K;Wheeler KA;Chavez FA;Mikus A;Dembinski R
• 通讯作者: Dembinski R

Metallo-nucleosides: synthesis and biological evaluation of hexacarbonyl dicobalt 5-alkynyl-2'-deoxyuridines.

金属核苷：六羰基二钴 5-炔基-2-脱氧尿苷的合成和生物学评价。

• DOI: 10.1039/b713371e
• 发表时间: 2008
• 期刊: Organic & biomolecular chemistry
• 影响因子: 3.2
• 作者: Sergeant,CraigD;Ott,Ingo;Sniady,Adam;Meneni,Srinivasarao;Gust,Ronald;Rheingold,ArnoldL;Dembinski,Roman
• 通讯作者: Dembinski,Roman

Zinc-catalyzed cycloisomerizations. Synthesis of substituted furans and furopyrimidine nucleosides.

锌催化环异构化。

• DOI: 10.1021/jo8007995
• 发表时间: 2008
• 期刊: The Journal of organic chemistry
• 作者: Sniady,Adam;Durham,Audrey;Morreale,MarcoS;Marcinek,Andrzej;Szafert,Slawomir;Lis,Tadeusz;Brzezinska,KrystynaR;Iwasaki,Takanori;Ohshima,Takashi;Mashima,Kazushi;Dembinski,Roman
• 通讯作者: Dembinski,Roman

Extension of furopyrimidine nucleosides with 5-alkynyl substituent: Synthesis, high fluorescence, and antiviral effect in the absence of free ribose hydroxyl groups.

• DOI: 10.1016/j.ejmech.2020.112884
• 发表时间: 2021-01-01
• 期刊: European journal of medicinal chemistry
• 影响因子: 6.7
• 作者: Kaczmarek R;Twardy DJ;Olson TL;Korczyński D;Andrei G;Snoeck R;Dolot R;Wheeler KA;Dembinski R
• 通讯作者: Dembinski R