Breast Cancer: Role of Early Detection, Treatment and P*

描述（由申请人提供）： 计划将早期开发的随机模型应用于与美国人口相关的乳腺癌问题。将研究的问题包括：估计2005-2020年期间美国乳腺癌死亡率;调查亚人群的死亡率;例如，非洲裔美国人、未保险人群和各种情况;继续调查最佳筛查时间表;调查DCIS后浸润性乳腺癌SEER中报告不足的作用;调查服用他莫昔芬或瑞洛昔芬作为预防药物的妇女人数增加对死亡率的影响;开发一个公共网站（a）允许研究人员利用我们的理论乳腺癌模型和（B）向公众传达乳腺癌的预测死亡率和任何筛查项目的假阳性率。

DESCRIPTION (provided by applicant): It is planned to apply the stochastic model developed earlier to breast cancer issues associated with the U.S. population. Among the issues which will be studied are: estimating the U.S. breast cancer mortality for the period 2005-2020; investigate mortality for sub-populations; e.g. African-American, uninsured population and various scenarios; continue investigations of optimal screening schedules; investigate the role of the underreporting in SEER of invasive breast cancer following DCIS; investigate the influence on mortality if the number of women taking tamoxifen or reloxifene as a preventive agent is increased; develop a public web site (a) which will allow investigators to make use of our theoretical breast cancer model and (b) to communicate to the general public the breast cancer predicted mortality and false positive rate for any screening program.