DOXYCYCLINE FOR BLEEDING IN PROGESTIN ONLY CONTRACEPTORS

强力霉素治疗仅使用孕激素的避孕者的出血

• 批准号: 7086287
• 负责人: DAVID Fitzgerald ARCHER
• 金额: $ 31.08万
• 依托单位: EASTERN VIRGINIA MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-27 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7086287
• 关键词: angiogenesis factor; chemoprevention; clinical research; clinical trials; cytokine; drug adverse effect; drug delivery systems; endometrium; enzyme linked immunosorbent assay; female; female antifertility drug; genetic polymorphism; genetic susceptibility; hemorrhage; human therapy evaluation; levonorgestrel; medroxyprogesterone; metalloendopeptidases; microarray technology; patient oriented research; pharmacogenetics; progestins; reproductive system pharmacology; tetracyclines; tissue /cell culture; women' s health

DESCRIPTION (provided by applicant): Clinically, a high percentage of women using progestin-only contraception experience breakthrough bleeding spotting that causes impaired lifestyle and results in decreased compliance with this contraceptive method. There is a need for an effective, low-cost, easily adapted treatment to reduce the bleeding and spotting in progestin only contraceptives. The molecular environment of the endometrium of women with breakthrough bleeding [BTB] and spotting, like many other inflammatory disorders, contains abnormally high levels of pro-inflammatory cytokines (TNF-alpha and IL-1beta)and abnormally high levels of proteases (matrix metalloproteinases [MMPs] and neutrophil elastase), which prevent normal tissue repair. Doxycycline [DOX] is an inexpensive, FDA approved antibiotic that inhibits MMPs, TACE activity, and reduces NO synthesis. The therapeutic benefit of DOX in animal models and clinical studies of periodontal and ulcerative diseases is due to its inhibition of MMPs, not to its antibiotic effect. We do not anticipate any reduction in contraceptive efficacy with the use of DOX. We propose to clinically evaluate DOX treatment of progestin-only contraceptive induced BTB and spotting, and to biochemically characterize the endometrial molecular biologic changes that occur in DOX treated patients. If successful, DOX treatment could become an important adjuvant for treatment of this and possibly other inflammatory disorders effecting reproductive tract tissues.

描述（由申请人提供）：临床上，使用单孕激素避孕的妇女中有很大一部分经历了突破性出血，这导致生活方式受损，并导致这种避孕方法的依从性降低。

项目成果

Effects of doxycycline on serum and endometrial levels of MMP-2, MMP-9 and TIMP-1 in women using a levonorgestrel-releasing subcutaneous implant.

多西环素对使用左炔诺孕酮释放皮下植入物的女性血清和子宫内膜 MMP-2、MMP-9 和 TIMP-1 水平的影响。

• DOI: 10.1016/j.contraception.2008.12.010
• 发表时间: 2009
• 期刊: Contraception
• 影响因子: 2.9
• 作者: Zhao,Shumei;Choksuchat,Chainarong;Zhao,Yueqin;Ballagh,SusanA;Kovalevsky,GeorgeA;Archer,DavidF
• 通讯作者: Archer,DavidF

Levonorgestrel effects on serum androgens, sex hormone-binding globulin levels, hair shaft diameter, and sexual function.

左炔诺孕酮对血清雄激素、性激素结合球蛋白水平、毛干直径和性功能的影响。

• DOI: 10.1016/j.fertnstert.2008.12.095
• 发表时间: 2010
• 期刊: Fertility and sterility
• 影响因子: 6.7
• 作者: Kovalevsky,George;Ballagh,SusanA;Stanczyk,FrankZ;Lee,Jennifer;Cooper,Joann;Archer,DavidF
• 通讯作者: Archer,DavidF

Effects of progesterone, levonorgestrel and medroxyprogesterone acetate on apoptosis in human endometrial endothelial cells.

黄体酮、左炔诺孕酮和醋酸甲羟孕酮对人子宫内膜内皮细胞凋亡的影响。

• DOI: 10.1016/j.contraception.2008.08.008
• 发表时间: 2009
• 期刊: Contraception
• 影响因子: 2.9
• 作者: Choksuchat,Chainarong;Zhao,Shumei;Deutch,ToddD;Kimble,ThomasD;Archer,DavidF
• 通讯作者: Archer,DavidF

Retraction notice to Doxycycline Alters the Expression of Matrix Metalloproteases in the Endometrial Cells Exposed to Ovarian Steroids and Pro-inflammatory Cytokine JRI 73/2 (April 2017);118-129.

强力霉素的撤回通知会改变暴露于卵巢类固醇和促炎细胞因子 JRI 73/2 的子宫内膜细胞中基质金属蛋白酶的表达（2017 年 4 月）；118-129。

• DOI: 10.1016/j.jri.2017.11.002
• 发表时间: 2018
• 期刊: Journal of reproductive immunology
• 影响因子: 3.4
• 作者: Li,Rongxiu;Luo,Xiaoping;Archer,DavidF;Chegini,Nasser
• 通讯作者: Chegini,Nasser